ArticleArchives of rheumatology2017
Is There a Possible Neuropathic Pain Component in Knee Osteoarthritis?
Article in Archives of rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04995250 (Effects of Corrective Exercise Training for Improving Neuropathic Pain and Function in Knee Osteoarthritis), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Corrective Exercise Training for Improving Neuropathic Pain and Function in Knee Osteoarthritis
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression.CartilagePooled it
- The Association of Neuropathic Pain with Function, Disease Severity, Emotional Status, Sleep Disturbance, and Quality of Life in Patients with Knee Osteoarthritis.Journal of clinical medicine · 2026Article
- Clinical phenotypes of neuropathic pain and central sensitization in patients with knee osteoarthritis: demographic data, radiographic severity, and pain intensity.BMC musculoskeletal disorders · 2026Article
- Prevalence and Association of Neuropathic Pain and Central Sensitization in Participants with Knee Osteoarthritis: Establishing a Cutoff Score for the Central Sensitization Inventory.Journal of pain research · 2026Article
- Neuropathic pain in knee osteoarthritis: Prevalence, diagnosis, and clinical implications.Joint diseases and related surgery · 2025Article
- A Mediation Appraisal of Neuropathic-like Symptoms, Pain Catastrophizing, and Central Sensitization-Related Signs in Adults with Knee Osteoarthritis-A Cross-Sectional Study.Journal of personalized medicine · 2025Article
- Neuropathic Pain in Patients with Knee Osteoarthritis: Relation with Comorbidities and Functional Status.Current rheumatology reviews · 2025Article
- Analysis of LINC00472 as a biomarker of osteoarthritis and its clinical value.Archives of rheumatology · 2024Article
- Platelet-rich plasma alleviates neuropathic pain in osteoarthritis by downregulating microglial activation.BMC musculoskeletal disorders · 2024Article
- Neuropathic-like symptoms and central sensitization related signs and symptoms negatively affect the functional performance of patients with knee osteoarthritis - a cross-sectional study.Osteoarthritis and cartilage open · 2023Article
- The correlation between clinical and radiological severity of osteoarthritis of the knee.SICOT-J · 2022Article
- Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping.RMD open · 2021Article
- Neuropathic pain in knee osteoarthritis.Advances in rheumatology (London, England) · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to investigate the neuropathic pain (NP) component in patients with osteoarthritis (OA) of the knee and its association with physical function, risk factors, and stages of OA. PATIENTS AND
methodsOne hundred and nine patients (16 males, 93 females; mean age 62.5±8.5 years; range 44 to 81 years) diagnosed with knee OA according to the American College of Rheumatology criteria were enrolled in this study between July 2014 and June 2015. Patients were evaluated with visual analog scale for pain severity, PainDETECT questionnaire for presence and severity of neuropathic pain, Western Ontario and McMaster Universities osteoarthritis index for physical function, and the Kellgren-Lawrence system for severity of OA. Presence of the associated risk factors were also questioned.
resultsA total of 12 patients (11%) were classified as having likely NP and 23 patients (21.1%) were classified as having possible NP. PainDETECT scores were significantly correlated with the visual analog scale scores and Western Ontario and McMaster Universities osteoarthritis index pain, physical function and total scores. Patients with neuropathic pain had significantly longer symptom duration than the patients without NP. However, we found no relationship between the other risk factors and NP.
conclusionThis study demonstrated that some of the knee OA patients had a NP component as the underlying cause of knee pain. Patients with NP had longer symptom duration, increased severity of pain, and disability. Therefore, the presence of NP component in these patients should be considered. Once it is determined, appropriate intervention strategies for NP should be incorporated in the routine treatment modalities of knee OA.
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