Evidence map›Paper›PMID 29900935›Full record

ArticleArchives of rheumatology2016

Association of rs11209032 and rs1004819 Polymorphisms in Interleukin-23 Receptor Gene With Ankylosing Spondylitis.

Müjgan Özdemir Erdoğan, Tuğba Şule Çankaya, Alper Murat Ulaşli, Saliha Handan Yildiz, Evrim Suna Arikan Terzi, Tuba Çavdar, Ümit Dündar, Mustafa Solak

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Müjgan Özdemir ErdoğanDepartment of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey.
Tuğba Şule ÇankayaDepartment of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey.
Alper Murat UlaşliDepartment of Physical Medicine and Rehabilitation, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey.
Saliha Handan YildizDepartment of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey.
Evrim Suna Arikan TerziDepartment of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey.
Tuba ÇavdarDepartment of Physical Medicine and Rehabilitation, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey.
Ümit DündarDepartment of Physical Medicine and Rehabilitation, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey.
Mustafa SolakDepartment of Medical Genetics, Medical Faculty of Afyon Kocatepe University, Afyonkarahisar, Turkey.
Afyon Kocatepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to investigate the distribution of human leukocyte antigen B27 (HLA-B27) alleles (+/-) and interleukin-23 receptor (IL-23R) gene rs11209032 and rs1004819 polymorphisms among ankylosing spondylitis (AS) patients in a Turkish cohort. PATIENTS AND

methodsThe study sample comprised 106 AS patients (89 males, 18 females; mean age 38.9±10 years; range 19 to 65 years) and 82 healthy controls (70 males, 12 females; mean age 32.15±7.07 years; range 19 to 51 years). Distribution of HLA-B27 alleles (+)/(-) in AS patients were observed by reverse hybridization technique. Genotyping of IL-23R rs11209032 and rs1004819 polymorphisms of AS patients and healthy controls were performed by real time polymerase chain reaction.

resultsOf the AS patients, 69 (65.1%) were HLA-B27 positive. Distribution of rs11209032 genotype frequencies in AS group were 31.1% for GG, 50.9% for GA, and 17.9% for AA; while in control group, it was 34.1% for GG, 53.7% for GA, and 12.2% for AA. Distribution of rs1004819 genotype frequencies in AS group were 30.2% for CC, 52.8% for CT, and 17.0% for TT; while in control group, it was 42.7% for CC, 46.3% for CT, and 11.0% for TT. There was no significant difference between AS patients and controls in terms of genotype frequencies of IL-23R gene rs11209032 and rs1004819 polymorphisms.

conclusionNo association was found between AS and IL23R rs11209032 and rs1004819 polymorphisms in this Turkish AS cohort.

Indexed as

Ankylosing spondylitishuman leukocyte antigen B27interleukin-23 receptor genepolymorphism

Identifiers

PMID29900935
PMCPMC5827843
OpenAlexW2342513397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.