Evidence map›Paper›PMID 29900649›Full record

ArticleCellular microbiology2018

Rounding precedes rupture and breakdown of vacuolar membranes minutes before malaria parasite egress from erythrocytes.

Svetlana Glushakova, Josh R Beck, Matthias Garten, Brad L Busse, Armiyaw S Nasamu, Tatyana Tenkova-Heuser, John Heuser, Daniel E Goldberg, Joshua Zimmerberg

Open access · greenAbstract read
In one paragraph

Article in Cellular microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Frontiers in parasitology · 2026
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  7. Activation of themBio · 2023
    Article
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  10. Efficient generation of mNeonGreenFrontiers in cellular and infection microbiology · 2022
    Article
  11. The Type III Secretion Effector CteG Mediates Host Cell Lytic Exit ofFrontiers in cellular and infection microbiology · 2022
    Article
  12. Designing antimalarials that break into cells to lock down parasites.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Malaria parasite egress at a glance.Journal of cell science · 2021
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Svetlana GlushakovaSection on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Josh R BeckDivision of Infectious Diseases, Department of Medicine, Washington University, St. Louis, Missouri.
Matthias GartenSection on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Brad L BusseSection on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Armiyaw S NasamuDivision of Infectious Diseases, Department of Medicine, Washington University, St. Louis, Missouri.
Tatyana Tenkova-HeuserSection on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
John HeuserSection on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Daniel E GoldbergDivision of Infectious Diseases, Department of Medicine, Washington University, St. Louis, Missouri.
Joshua ZimmerbergSection on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.ORCID 0000-0002-1707-3789
National Institutes of Health · USWashington University in St. Louis · USIowa State University · US

Funding

Membrane Remodeling in Viral Infection, Parasite Replication, and Traumatic Brain InjuryZIAHD001409 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ZIMMERBERG, JOSHUA · 2009 to 2025
$29.9M
Plasmepsin X function in PlasmodiumR01AI138447 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2018 to 2022
$1.9M
Erythrocyte Subversion by Malaria Parasite Exported EffectorsR00HL133453 · NHLBI · IOWA STATE UNIVERSITY · PI BECK, JOSH RYAN · 2017 to 2019
$747k
Erythrocyte Subversion by Malaria Parasite Exported EffectorsK99HL133453 · NHLBI · WASHINGTON UNIVERSITY · PI BECK, JOSH RYAN · 2016 to 2017
$166k
Intramural NIH HHS ZIA HD001409NHLBI NIH HHS K99 HL133453NHLBI NIH HHS R00 HL133453NIAID NIH HHS R01 AI138447
6 · The paper itself

Abstract

Because Plasmodium falciparum replicates inside of a parasitophorous vacuole (PV) within a human erythrocyte, parasite egress requires the rupture of two limiting membranes. Parasite Ca

Indexed as

CalciumErythrocyte MembraneErythrocytesFluorescent DyesHumansMalaria, FalciparumPlasmodium falciparumProtein Serine-Threonine KinasesVacuolesCalciumFluorescent DyesProtein Serine-Threonine Kinasesinfectionmembranemicrobial-cell interactionmicrobial structureparasitophorous vacuolePlasmodium falciparum

Identifiers

PMID29900649
PMCPMC6368063
OpenAlexW2808016971

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.