Evidence map›Paper›PMID 29900525›Full record

ArticleBritish journal of pharmacology2018

Noradrenaline up-regulates volume-regulated chloride current by PKA-independent cAMP/exchange protein activated by cAMP pathway in human atrial myocytes.

Guo-Sheng Xiao, Yan-Hui Zhang, Yan Wang, Hai-Ying Sun, Clive M Baumgarten, Gui-Rong Li

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Guo-Sheng XiaoXiamen Cardiovascular Hospital, Medical College of Xiamen University, Xiamen, Fujian, China.
Yan-Hui ZhangXiamen Cardiovascular Hospital, Medical College of Xiamen University, Xiamen, Fujian, China.
Yan WangXiamen Cardiovascular Hospital, Medical College of Xiamen University, Xiamen, Fujian, China.
Hai-Ying SunDepartment of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong, China.
Clive M BaumgartenDepartment of Physiology and Biophysics, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Gui-Rong LiXiamen Cardiovascular Hospital, Medical College of Xiamen University, Xiamen, Fujian, China.ORCID 0000-0002-9437-2280
Xiamen University · CNUniversity of Hong Kong · HKVirginia Commonwealth University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAdrenergic regulation of cell volume-regulated chloride current (I EXPERIMENTAL APPROACH: Conventional whole-cell patch voltage-clamp techniques were used to record membrane current in human atrial myocytes. I KEY

resultsI CONCLUSION AND IMPLICATIONS: These data show that I

Indexed as

Cells, CulturedChloridesCyclic AMPCyclic AMP-Dependent Protein KinasesGuanine Nucleotide Exchange FactorsHeart AtriaHumansMyocytes, CardiacNorepinephrineUp-RegulationChloridesCyclic AMPCyclic AMP-Dependent Protein KinasesGuanine Nucleotide Exchange FactorsNorepinephrineRAPGEF3 protein, human

Identifiers

PMID29900525
PMCPMC6057899
OpenAlexW2808598549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.