Evidence map›Paper›PMID 29900497›Full record

ReviewSub-cellular biochemistry2018

The Retrovirus Capsid Core.

Wei Zhang, Luiza M Mendonça, Louis M Mansky

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sub-cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Regulation and functions of the NLRP3 inflammasome in RNA virus infection.Frontiers in cellular and infection microbiology · 2023
    Review
  2. Review
  3. RNA Binding Properties of the Ty1 LTR-Retrotransposon Gag Protein.International journal of molecular sciences · 2021
    Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wei ZhangInstitute for Molecular Virology, Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, USA. zhangwei@umn.edu.
Luiza M MendonçaInstitute for Molecular Virology, Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, USA.
Louis M ManskyInstitute for Molecular Virology, Department of Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · US

Funding

HTLV-1 Particle Analysis and Gag InteractionsR01GM098550 · NIGMS · UNIVERSITY OF MINNESOTA · PI MANSKY, LOUIS M. · 2012 to 2020
$3.1M
HIV Gag lattice morphology and particle biogenesis - Administrative SupplementR01GM124279 · NIGMS · UNIVERSITY OF MINNESOTA · PI MANSKY, LOUIS M., MUELLER, JOACHIM D · 2017 to 2018
$1.4M
NIGMS NIH HHS R01 GM098550NIGMS NIH HHS R01 GM124279
6 · The paper itself

Abstract

The retrovirus capsid core is a metastable structure that disassembles during the early phase of viral infection after membrane fusion. The core is intact and permeable to essential nucleotides during reverse transcription, but it undergoes disassembly for nuclear entry and genome integration. Increasing or decreasing the stability of the capsid core has a substantial negative impact on virus infectivity, which makes the core an attractive anti-viral target. The retrovirus capsid core also encounters a variety of virus- and organism-specific host cellular factors that promote or restrict viral replication. This review describes the structural elements fundamental to the formation and stability of the capsid core. The physical and chemical properties of the capsid core that are critical to its functional role in reverse transcription and interaction with host cellular factors are highlighted to emphasize areas of current research.

Indexed as

Virus InternalizationAnimalsCapsidHumansRetroviridaeReverse TranscriptionVirus IntegrationVirus ReplicationCapsidCapsomerComparativeMaturationRestriction factorRetrovirusVirus-host interaction

Identifiers

PMID29900497
PMCPMC13104759
OpenAlexW2808248506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.