ArticleEuropean stroke journal2017
Estimating the number of UK stroke patients eligible for endovascular thrombectomy.
Article in European stroke journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 6 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Software with artificial intelligence-derived algorithms for analysing CT brain scans in people with a suspected acute stroke: a systematic review and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2024Pooled it
- Distinctions between the Koizumi and Zea Longa methods for middle cerebral artery occlusion (MCAO) model: a systematic review and meta-analysis of rodent data.Scientific reports · 2023Pooled it
- Artificial intelligence in the autonomous navigation of endovascular interventions: a systematic review.Frontiers in human neuroscience · 2023Pooled it
- Robotics in neurointerventional surgery: a systematic review of the literature.Journal of neurointerventional surgery · 2022Pooled it
- Therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis.BMJ open science · 2020Pooled it
- The Potential of Biomaterial-Based Approaches as Therapies for Ischemic Stroke: A Systematic Review and Meta-Analysis of Pre-clinical Studies.Frontiers in neurology · 2019Pooled it
- Breaking barriers in stroke care: the role of peripheral interventional radiologists in mechanical thrombectomy.La Radiologia medica · 2026Article
- Barriers Associated with Help-Seeking for Stroke Symptoms Despite Public Awareness Campaigns: A Cross-Sectional Study.NeuroSci · 2026Article
- The Thrombectomy Dilemma in Stroke Patients With Active Cancer: To Treat or Not to Treat?Journal of stroke · 2026Review
- Changing trends in epidemiology, care and outcome of ischemic stroke over 25 years: a large population-based study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- A Position Statement on Endovascular Models and Effectiveness Metrics for Mechanical Thrombectomy Navigation, on Behalf of the Stakeholder Taskforce for Artificial Intelligence-Assisted Robotic Thrombectomy (START).Journal of the American Heart Association · 2026Article
- Strategies for Navigating Magnetic Microrobots in Neurovascular Networks: A Numerical Analysis.Small science · 2025Article
- Fingolimod as a Neuroprotective Agent in Ischemic Stroke: A Review of Preclinical and Clinical Evidence.Journal of clinical medicine · 2025Review
- Article
- Economic burden of cardiovascular disease in the United Kingdom.European heart journal. Quality of care & clinical outcomes · 2025Article
- Benchmarking reinforcement learning algorithms for autonomous mechanical thrombectomy.International journal of computer assisted radiology and surgery · 2025Article
- Reinforcement learning for safe autonomous two-device navigation of cerebral vessels in mechanical thrombectomy.International journal of computer assisted radiology and surgery · 2025Article
- Detrimental influence of Arginase-1 in infiltrating macrophages on poststroke functional recovery and inflammatory milieu.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The impact of large core and late treatment trials: An update on the modelled annual thrombectomy eligibility of UK stroke patients.European stroke journal · 2024Article
- Autonomous navigation of catheters and guidewires in mechanical thrombectomy using inverse reinforcement learning.International journal of computer assisted radiology and surgery · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
introductionEndovascular thrombectomy is a highly effective treatment for acute ischemic stroke due to large arterial occlusion. Routine provision will require major changes in service configuration and workforce. An important first step is to quantify the population of stroke patients that could benefit. We estimated the annual UK population suitable for endovascular thrombectomy using standard or advanced imaging for patient selection. PATIENTS AND
methodsEvidence from randomised control trials and national registries was combined to estimate UK stroke incidence and define a decision-tree describing the endovascular thrombectomy eligible population.
resultsBetween 9620 and 10,920 UK stroke patients (approximately 10% of stroke admissions) would be eligible for endovascular thrombectomy annually. The majority (9140-9620) would present within 4 h of onset and be suitable for intravenous thrombolysis. Advanced imaging would exclude 500 patients presenting within 4 h, but identify an additional 1310 patients as eligible who present later. DISCUSSION: Information from randomised control trials and large registry data provided the evidence criterion for 9 of the 12 decision points. The best available evidence was used for two decision points with sensitivity analyses to determine how key branches of the tree affected estimates. Using the mid-point estimate for eligibility (9.6% of admissions) and assuming national endovascular thrombectomy coverage, 4280 patients would have reduced disability.
conclusionA model combining published trials and register data suggests approximately 10% of all stroke admissions in the UK are eligible for endovascular thrombectomy. The use of advanced imaging based on current published evidence did not have a major impact on overall numbers but could alter eligibility status for 16% of cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.