ArticleEuropean stroke journal2017
Efficacy of early cognitive-linguistic treatment for aphasia due to stroke: A randomised controlled trial (Rotterdam Aphasia Therapy Study-3).
Article in European stroke journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Efficacy and safety of repetitive transcranial magnetic therapy for post-stroke aphasia: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neurology · 2025Pooled it
- Does acupuncture therapy improve language function of patients with aphasia following ischemic stroke? A systematic review and meta-analysis.NeuroRehabilitation · 2022Pooled it
- Predictors of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis.Stroke · 2021Pooled it
- A Systematic Review of Transcranial Direct Current Stimulation in Primary Progressive Aphasia: Methodological Considerations.Frontiers in aging neuroscience · 2021Pooled it
- Predicting Outcomes of Language Rehabilitation: Prognostic Factors for Immediate and Long-Term Outcomes After Aphasia Therapy.Journal of speech, language, and hearing research : JSLHR · 2023Trial
- A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study.International journal of stroke : official journal of the International Stroke Society · 2021Trial
- Aphasia Rehabilitation in India: Current Practices and Future Directions.Healthcare (Basel, Switzerland) · 2026Article
- Towards More Effective Treatments in Stroke-Induced Aphasia: A Discussion of the Evolution of Treatment Programs.Advances in experimental medicine and biology · 2026Review
- Machine learning predicts significant improvement in motor aphasia with tongue acupuncture.Frontiers in neurology · 2025Article
- Article
- Validation of a Cantonese Version of the Amsterdam-Nijmegen Everyday Language Test (CANELT): A functional approach.PloS one · 2024Article
- Insights gained over 60 years on factors shaping post-stroke aphasia recovery: A commentary on Vignolo (1964).Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Therapies and Challenges in the Post-Stroke Aphasia Rehabilitation Arena: Current and Future Prospects.Medicina (Kaunas, Lithuania) · 2023Review
- Better long-term speech outcomes in stroke survivors who received early clinical speech and language therapy: What's driving recovery?Neuropsychological rehabilitation · 2022Article
- Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia Therapy.Journal of stroke · 2022Review
- Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications.Frontiers in human neuroscience · 2022Review
- Treatment of post-stroke aphasia: A narrative review for stroke neurologists.International journal of stroke : official journal of the International Stroke Society · 2021Review
- Current Approaches to the Treatment of Post-Stroke Aphasia.Journal of stroke · 2021Review
- The verbal, non-verbal and structural bases of functional communication abilities in aphasia.Brain communications · 2020Article
- Language recovery following stroke.The Clinical neuropsychologist · 2019Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOne third of patients with acute stroke have aphasia. The majority receive speech and language therapy. There is evidence for a beneficial effect of speech and language therapy on restoring communication, but it is unknown whether and how efficacy of speech and language therapy is influenced by timing of treatment. We studied whether speech and language therapy early after stroke by way of intensive cognitive-linguistic treatment is more effective than no speech and language therapy in the Rotterdam Aphasia Therapy Study-3, a multicentre randomised single-blind trial. METHODS AND PATIENTS: Stroke patients with first-ever aphasia were randomised within 2 weeks of onset to either 4 weeks of early intensive cognitive-linguistic treatment (1 h/day) or no language treatment. Hereafter, both groups received regular speech and language therapy. Primary outcome was the score on the Amsterdam-Nijmegen Everyday Language Test, measuring everyday verbal communication, 4 weeks after randomisation. Secondary outcomes were Amsterdam-Nijmegen Everyday Language Test at 3 and 6 months. The study was powered to detect a clinically relevant difference of four points on the Amsterdam-Nijmegen Everyday Language Test.
resultsOf the 152 included patients, 80 patients were allocated to intervention. Median treatment intensity in the intervention-group was 24.5 h. The adjusted difference between groups in mean Amsterdam-Nijmegen Everyday Language Test-scores 4 weeks after randomisation was 0.39, 95% confidence interval: [-2.70 to 3.47],
conclusionFour weeks of intensive cognitive-linguistic treatment initiated within 2 weeks of stroke is not more effective than no language treatment for the recovery of post-stroke aphasia. Our results exclude a clinically relevant effect of very early cognitive-linguistic treatment on everyday language.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.