ArticleFrontiers in cardiovascular medicine2018
Translating GWAS Findings to Novel Therapeutic Targets for Coronary Artery Disease.
Article in Frontiers in cardiovascular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- BMI-genome interactions regulate global gene expression with emphasis in brain and gut.Cell genomics · 2026Article
- Multi-Omic Insight Into the Molecular Networks in the Pathogenesis of Coronary Artery Disease.Journal of the American Heart Association · 2025Article
- Review
- Genomic strategies for drug repurposing.Journal of the Egyptian National Cancer Institute · 2024Review
- Using Genomics to Identify Novel Therapeutic Targets for Aortic Disease.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- multi-GPA-Tree: Statistical approach for pleiotropy informed and functional annotation tree guided prioritization of GWAS results.PLoS computational biology · 2023Article
- Genome-wide association studies: utility and limitations for research in physiology.The Journal of physiology · 2023Article
- Ethnic, gender and other sociodemographic biases in genome-wide association studies for the most burdensome non-communicable diseases: 2005-2022.Human molecular genetics · 2023Article
- Evaluating the detection ability of a range of epistasis detection methods on simulated data for pure and impure epistatic models.PloS one · 2022Article
- Reproducibility in the UK biobank of genome-wide significant signals discovered in earlier genome-wide association studies.Scientific reports · 2021Article
- Repurposing Drugs to Treat Heart and Brain Illness.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank.Scientific reports · 2021Article
- Using functional genomics to advance the understanding of psoriatic arthritis.Rheumatology (Oxford, England) · 2020Review
- The Integrated Landscape of Biological Candidate Causal Genes in Coronary Artery Disease.Frontiers in genetics · 2020Article
- Network Modeling Approaches and Applications to Unravelling Non-Alcoholic Fatty Liver Disease.Genes · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The success of genome-wide association studies (GWAS) has significantly advanced our understanding of the etiology of coronary artery disease (CAD) and opens new opportunities to reinvigorate the stalling CAD drug development. However, there exists remarkable disconnection between the CAD GWAS findings and commercialized drugs. While this could implicate major untapped translational and therapeutic potentials in CAD GWAS, it also brings forward extensive technical challenges. In this review we summarize the motivation to leverage GWAS for drug discovery, outline the critical bottlenecks in the field, and highlight several promising strategies such as functional genomics and network-based approaches to enhance the translational value of CAD GWAS findings in driving novel therapeutics.
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