ArticleIranian journal of public health2018
Relationship between Serum Soluble Klotho Protein and Coronary Artery Calcification and Prognosis in Patients on Maintenance Hemodialysis.
Article in Iranian journal of public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies.Scientific reports · 2024Pooled it
- Correlation Between Soluble Klotho and Vascular Calcification in Chronic Kidney Disease: A Meta-Analysis and Systematic Review.Frontiers in physiology · 2021Pooled it
- Serum Alpha-Klotho and Coronary Atherosclerosis: Associations with Coronary CT Angiography Findings and Atherogenic Indices.Biomedicines · 2026Article
- Association of serum Klotho and fibroblast growth factor-23 levels with vascular calcification severity in patients with chronic kidney disease: an observational cohort study.International urology and nephrology · 2025Observational
- A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients.Open medicine (Warsaw, Poland) · 2025Article
- The association between klotho and kidney and cardiovascular outcomes: a comprehensive systematic review and meta-analysis.Clinical kidney journal · 2024Review
- The optimal cut-off values of Klotho for predicting all-cause and cardiovascular mortality among chronic kidney disease: results from NHANES.Scientific reports · 2024Article
- Klotho and lean mass as novel cardiovascular risk factors in hemodialysis patients.Clinical kidney journal · 2023Article
- Association between soluble α-klotho and mortality risk in middle-aged and older adults.Frontiers in endocrinology · 2023Article
- Klotho inversely relates with carotid intima- media thickness in atherosclerotic patients with normal renal function (eGFR ≥60 mL/min/1.73mFrontiers in endocrinology · 2023Article
- Targeting a Silent Disease: Vascular Calcification in Chronic Kidney Disease.International journal of molecular sciences · 2022Review
- The controversy of klotho as a potential biomarker in chronic kidney disease.Frontiers in pharmacology · 2022Review
- Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease.Scientific reports · 2021Article
- The prognostic value of soluble Klotho in patients with haemodialysis: a systematic review and meta-analysis.Therapeutic advances in chronic disease · 2020Article
- Association of Soluble Klotho Level with Adverse Outcomes in Patients on Maintenance Hemodialysis.Disease markers · 2020Article
- Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis.BMC nephrology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to investigate the relationship between serum soluble Klotho protein (sKlotho) level and coronary artery calcification (CAC) as well as prognosis in patients with maintenance hemodialysis (MHD).
methodsOverall, 128 adult patients with end-stage renal failure treated with MHD were collected in the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Zhejiang Province, China in 2013. Serum sKlotho was detected by ELISA and coronary artery calcification was measured by multi-slice spiral computed tomography (MSCT). With 36 months' follow-up, death notes such as cause of death and death time were recorded.
resultsPatients were divided into low sKlotho group and high sKlotho group. Age, blood phosphorus level, hypertension incidence and incidence of diabetes mellitus of the patients in low sKlotho group was significantly higher than that of high sKlotho group (
conclusionSKlotho can increase the degree of CAC. Although MHD patients with low sKlotho level had shorter survival time, sKlotho is not an independent risk factor in prediction of prognosis of MHD patients.
Indexed as
Identifiers
29900135PMC5996336W2802683278What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.