Evidence map›Paper›PMID 29900112›Full record

ArticleEuPA open proteomics2016

Set up of a protocol for rat plasma peptidomics in hemorrhagic shock model in presence of heparin.

Elisa Maffioli, Federico Aletti, Fabiana Santagata, Armando Negri, Marco H Santamaria, Frank A De Lano, Erik B Kistler, Geert W Schmid-Schönbein, Gabriella Tedeschi

Abstract read
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In one paragraph

Article in EuPA open proteomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elisa MaffioliFondazione Filarete, Viale Ortles, 22/4, 20139 Milan, Italy.
Federico AlettiDipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Via Ponzio, 34/5, 20133 Milan, Italy.
Fabiana SantagataFondazione Filarete, Viale Ortles, 22/4, 20139 Milan, Italy.
Armando NegriFondazione Filarete, Viale Ortles, 22/4, 20139 Milan, Italy.
Marco H SantamariaDepartment of Bioengineering, University of California, San Diego, 9500 Gilman Drive MC 0412, La Jolla, CA 92093-0412, USA.
Frank A De LanoDepartment of Bioengineering, University of California, San Diego, 9500 Gilman Drive MC 0412, La Jolla, CA 92093-0412, USA.
Erik B KistlerDepartment of Anesthesiology and Critical Care Medicine, University of California, San Diego and San Diego VASDHS (125) 3350, La Jolla, CA 92161-5085, USA.
Geert W Schmid-SchönbeinDepartment of Bioengineering, University of California, San Diego, 9500 Gilman Drive MC 0412, La Jolla, CA 92093-0412, USA.
Gabriella TedeschiFondazione Filarete, Viale Ortles, 22/4, 20139 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A preliminary mass spectrometry based shotgun protocol was set up to compare the peptidome of plasma samples from healthy and hemorrhagic shock rats with the aim of verifying the possible role of uncontrolled proteolytic activity in circulatory shock. Since the hemorrhagic shock model requires heparin as anticoagulant, a preliminary experiment using plasma sample obtained in the presence/absence of heparin from healthy rats was performed to determine whether its presence is fully compatible with the peptidomic protocol proposed. The entire protocol was tested in a pilot experiment to compare the peptidome of healthy or heparin-anticoagulated rats subjected to hemorrhagic shock.

Indexed as

Hemorrhagic shockHeparinMass spectrometryPeptidomicsProteolysis

Identifiers

PMID29900112
PMCPMC5988501

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.