Evidence map›Paper›PMID 29900104›Full record

ArticleEuPA open proteomics2016

Experimental setup for the identification of mitochondrial protease substrates by shotgun and top-down proteomics.

Alice Di Pierro, Heather Bondi, Chiara Monti, Luisa Pieroni, Enrico Cilio, Andrea Urbani, Tiziana Alberio, Mauro Fasano, Maurizio Ronci

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EuPA open proteomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alice Di PierroDepartment of Science and High Technology, University of Insubria, I-21052 Busto Arsizio, Italy.
Heather BondiDepartment of Science and High Technology, University of Insubria, I-21052 Busto Arsizio, Italy.
Chiara MontiDepartment of Science and High Technology, University of Insubria, I-21052 Busto Arsizio, Italy.
Luisa PieroniSanta Lucia IRCCS Foundation, I-00143 Rome, Italy.
Enrico CilioSanta Lucia IRCCS Foundation, I-00143 Rome, Italy.
Andrea UrbaniSanta Lucia IRCCS Foundation, I-00143 Rome, Italy.
Tiziana AlberioDepartment of Science and High Technology, University of Insubria, I-21052 Busto Arsizio, Italy.
Mauro FasanoDepartment of Science and High Technology, University of Insubria, I-21052 Busto Arsizio, Italy.
Maurizio RonciDept. of Medical, Oral and Biotechnological Sciences, University "G. D'Annunzio" of Chieti-Pescara, I-66013 Chieti, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria possess a proteolytic system that contributes to the regulation of mitochondrial dynamics, mitochondrial biogenesis and mitophagy. We aimed at the identification by bottom-up proteomics of altered protein processing due to the activation of mitochondrial proteases in a cellular model of impaired dopamine homeostasis. Moreover, we optimized the conditions for top-down proteomics to identify the cleavage site sequences.

Indexed as

ElectroelutionMitochondriaProteaseShotgunTop-down

Identifiers

PMID29900104
PMCPMC5988556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.