Evidence map›Paper›PMID 29900060›Full record

ArticleOncoimmunology

Transforming the prostatic tumor microenvironment with oncolytic virotherapy.

Matthew J Atherton, Kyle B Stephenson, Fanny Tzelepis, David Bakhshinyan, Jake K Nikota, Hwan Hee Son, Anna Jirovec, Charles Lefebvre, Anna Dvorkin-Gheva, Ali A Ashkar and 9 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Personalizing Oncolytic Immunovirotherapy Approaches.Molecular diagnosis & therapy · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Immunology of Adenoviral Vectors in Cancer Therapy.Molecular therapy. Methods & clinical development · 2019
    Review
  20. Updates on Oncolytic Virus Immunotherapy for Cancers.Molecular therapy oncolytics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Matthew J AthertonMcMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
Kyle B StephensonTurnstone Biologics, Ottawa, Canada.
Fanny TzelepisCentre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ottawa, Canada.
David BakhshinyanMcMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Canada.
Jake K NikotaTurnstone Biologics, Ottawa, Canada.
Hwan Hee SonCentre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ottawa, Canada.
Anna JirovecCentre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ottawa, Canada.
Charles LefebvreStojdl Lab, CHEO Research Institute, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Anna Dvorkin-GhevaMcMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
Ali A AshkarMcMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
Yonghong WanMcMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
David F StojdlTurnstone Biologics, Ottawa, Canada.
Eric C BelangerDepartment of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada.
Rodney H BreauDepartment of Surgery, The Ottawa Hospital, Ottawa, Canada.
John C BellTurnstone Biologics, Ottawa, Canada.
Fred SaadDepartment of Surgery, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Canada.
Sheila K SinghMcMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Canada.
Jean-Simone DialloCentre for Cancer Therapeutics, The Ottawa Hospital Research Institute, Ottawa, Canada.
Brian D LichtyMcMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
McMaster University Medical Centre · CAUniversity of Ottawa · CAOttawa Hospital · CAChildren's Hospital of Eastern Ontario · CAMcMaster University · CACentre Hospitalier de l’Université de Montréal · CA

Funding

CIHR MOP 130317
6 · The paper itself

Abstract

Prostate cancer (PCa) was estimated to have the second highest global incidence rate for male non-skin tumors and is the fifth most deadly in men thus mandating the need for novel treatment options. MG1-Maraba is a potent and versatile oncolytic virus capable of lethally infecting a variety of prostatic tumor cell lines alongside primary PCa biopsies and exerts direct oncolytic effects against large TRAMP-C2 tumors

Indexed as

MG1-Marabaprostatic carcinomaSTEAPtumor microenvironmentvaccination

Identifiers

PMID29900060
PMCPMC5993491
OpenAlexW2793301215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.