Evidence map›Paper›PMID 29900007›Full record

ArticleCardio-oncology (London, England)2018

Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines.

Olga H Toro-Salazar, Ji Hyun Lee, Kia N Zellars, Paige E Perreault, Kathryn C Mason, Zhu Wang, Kan N Hor, Eileen Gillan, Caroline J Zeiss, Daniel M Gatti and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardio-oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03211520 (Magnetic Resonance Imaging), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03211520 completednot on this map

Magnetic Resonance Imaging:A Window to Anthracycline Toxicity

TypeobservationalSponsorConnecticut Children's Medical CenterRan2013 to 2023Enrolled13ConditionsCardiac Complications
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
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  9. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Olga H Toro-SalazarConnecticut Children's Medical Center, 282 Washington Street, Hartford, CT 06106, USA.
Ji Hyun LeeConnecticut Children's Medical Center, 282 Washington Street, Hartford, CT 06106, USA.
Kia N ZellarsUniversity of South Carolina School of Medicine, Columbia, SC, USA.
Paige E PerreaultUniversity of South Carolina School of Medicine, Columbia, SC, USA.
Kathryn C MasonUniversity of South Carolina School of Medicine, Columbia, SC, USA.
Zhu WangConnecticut Children's Medical Center, 282 Washington Street, Hartford, CT 06106, USA.
Kan N HorNationwide Children's Hospital, Columbus, OH, USA.
Eileen GillanConnecticut Children's Medical Center, 282 Washington Street, Hartford, CT 06106, USA.
Caroline J ZeissYale University School of Medicine, New Haven, CT, USA.
Daniel M GattiJackson Laboratories, Bar Harbor, ME, USA.
Brooke T DaveyConnecticut Children's Medical Center, 282 Washington Street, Hartford, CT 06106, USA.
Shelby KuttyUniversity of Nebraska, Omaha, NE, USA.
Bruce T LiangPat and Jim Calhoun Cardiology Center, University of Connecticut Health Center, Farmington, CT, USA.
Francis G SpinaleUniversity of South Carolina School of Medicine, Columbia, SC, USA.
Connecticut Children's Medical Center · USUniversity of South Carolina · USUConn Health · USJackson Laboratory · USNationwide Children's Hospital · USUniversity of Nebraska at Omaha · USYale University · US

Funding

Localized Targeting of Matrix Proteases Following Myocardial InfarctionR01HL111090 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BURDICK, JASON A, SPINALE, FRANCIS G · 2012 to 2015
$2.0M
Therapeutic Targeting of Tissue Inhibitor-4 in Hypertrophy and FailureR01HL130972 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SPINALE, FRANCIS G · 2016 to 2019
$1.9M
NHLBI NIH HHS R01 HL111090NHLBI NIH HHS R01 HL130972
6 · The paper itself

Abstract

backgroundAnthracycline induced cardiomyopathy is a major cause of mortality and morbidity among pediatric cancer survivors. It has been postulated that oxidative stress induction and inflammation may play a role in the pathogenesis of this process. Accordingly, the present study performed an assessment of biomarker profiles and functional imaging parameters focused upon potential early determinants of anthracycline induced cardiomyopathy.

methodsPatients (10-22 years) were prospectively enrolled between January 2013 and November 2014. Thirteen subjects completed the study and underwent serial cardiac magnetic resonance imaging and plasma biomarker profiling performed 24-48 h after the first anthracycline dose and at set dose intervals. In addition, we collected plasma samples from 62 healthy controls to examine normal plasma biomarker profiles.

resultsLeft ventricular ejection fraction (LVEF) decreased from 64.3 ± 6.2 at the first visit to 57.5 ± 3.3 (

conclusionsAsymptomatic pediatric patients exposed to anthracycline therapy develop abnormal strain parameters at lower cumulative doses when compared to changes in EF. A differential biomarker signature containing both inflammatory and matrix domains occur early in anthracycline treatment. Dynamic changes in these domains occur with increased anthracycline doses and progression to anthracycline induced cardiomyopathy. These findings provide potential prognostic and mechanistic insights into the natural history of anthracycline induced cardiomyopathy. TRIAL REGISTRATION NUMBER: NCT03211520 Date of Registration February 13, 2017, retrospectively registered.

Indexed as

AnthracyclinesCardiotoxicityGlobal systolic functionMyocardial strain

Identifiers

PMID29900007
PMCPMC5995570
OpenAlexW2802122808

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.