Evidence map›Paper›PMID 29899893›Full record

ArticleChemical science2016

A thorough anion-π interaction study in biomolecules: on the importance of cooperativity effects.

Xavier Lucas, Antonio Bauzá, Antonio Frontera, David Quiñonero

Abstract read
In one paragraph

Article in Chemical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Article
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  4. Hidden Interactions: Quantum Perspectives in Drug Design.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  5. Article
  6. Review
  7. Review
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  9. Anion-π interaction-induced phase separation as a prebiotic pathway to oxygenation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Appendix.Reviews of physiology, biochemistry and pharmacology · 2025
    Review
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  15. Article
  16. Article
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xavier LucasPharmaceutical Bioinformatics , Institute of Pharmaceutical Sciences , Albert-Ludwigs-University , Hermann-Herder-Str. 9 , D-79104 Freiburg , Germany . Email: xavier.lucas@pharmazie.uni-freiburg.de ; ; Tel: +34 971173498.ORCID 0000-0003-0887-3976
Antonio BauzáDepartament de Química , Universitat de les Illes Balears , Crta. de Valldemossa km 7.5 , 07122 Palma de Mallorca , Spain . Email: david.quinonero@uib.es.
Antonio FronteraDepartament de Química , Universitat de les Illes Balears , Crta. de Valldemossa km 7.5 , 07122 Palma de Mallorca , Spain . Email: david.quinonero@uib.es.ORCID 0000-0001-7840-2139
David QuiñoneroDepartament de Química , Universitat de les Illes Balears , Crta. de Valldemossa km 7.5 , 07122 Palma de Mallorca , Spain . Email: david.quinonero@uib.es.ORCID 0000-0002-9661-9881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noncovalent interactions have a constitutive role in the science of intermolecular relationships, particularly those involving aromatic rings such as π-π and cation-π. In recent years, anion-π contact has also been recognized as a noncovalent bonding interaction with important implications in chemical processes. Yet, its involvement in biological processes has been scarcely reported. Herein we present a large-scale PDB analysis of the occurrence of anion-π interactions in proteins and nucleic acids. In addition we have gone a step further by considering the existence of cooperativity effects through the inclusion of a second noncovalent interaction,

Identifiers

PMID29899893
PMCPMC5967298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.