ArticleInternational journal of obesity (2005)2018
Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE.
Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06213883 (Characterizing Acute Exercise Response in Restrictive Eating Disorders), which is not on this map. Cited by 210 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterizing Acute Exercise Response in Restrictive Eating Disorders
Who cites it
210 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Reviewing the association between motor competence and physical activity from a behavioral genetic perspective.Frontiers in psychology · 2025Pooled it
- Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- Genetic estimation of causalities between educational attainment with common digestive tract diseases and the mediating pathways.BMC gastroenterology · 2024Pooled it
- Role of lifestyle factors in mediating the effect of educational attainment on bone mineral density: a Mendelian randomization study.Archives of osteoporosis · 2023Pooled it
- Testing the causal relationships of physical activity and sedentary behaviour with mental health and substance use disorders: a Mendelian randomisation study.Molecular psychiatry · 2023Pooled it
- Lifestyle factors, metabolic factors and socioeconomic status for pelvic organ prolapse: a Mendelian randomization study.European journal of medical research · 2023Pooled it
- Investigating the relationship between depression and breast cancer: observational and genetic analyses.BMC medicine · 2023Pooled it
- Lifestyle factors, serum parameters, metabolic comorbidities, and the risk of kidney stones: a Mendelian randomization study.Frontiers in endocrinology · 2023Pooled it
- Relationships between accelerometer-measured and multiple sclerosis: a 2-sample Mendelian randomization study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: a Mendelian randomization analysis.Lipids in health and disease · 2020Pooled it
- Genetic variation in CADM2 as a link between psychological traits and obesity.Scientific reports · 2019Pooled it
- Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-Sample Mendelian Randomization Study.JAMA psychiatry · 2019Pooled it
- Article
- Identification of PTPRR gene associated with cirrhosis and sarcopenia based on bioinformatics and machine learning.European journal of clinical nutrition · 2026Article
- The role of ucOCN in aerobic exercise induced amelioration of autism spectrum disorder phenotypes.iScience · 2026Article
- Plasma Proteomic Signatures of Physical Activity Provide Insights into Biological Impacts and its Protective Role against Dementia.Medicine and science in sports and exercise · 2026Observational
- Article
- Global, regional, and national burden of non-rheumatic calcific aortic valve disease from 1990 to 2021, with projections of incidence to 2050: a systematic analysis of the global burden of disease study 2021 and Mendelian randomization analysis.Journal of cardiothoracic surgery · 2026Article
- Body mass index, physical activity, and epigenetic aging: a cross-population study.Clinical epigenetics · 2026Observational
- Cognitive reserve in non-affective first-episode psychosis: contributions of polygenic scores, early clinical features, and environment.Psychological medicine · 2026Article
150 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors.
Funding
Abstract
BACKGROUND/
objectivesPhysical activity (PA) protects against a wide range of diseases. Habitual PA appears to be heritable, motivating the search for specific genetic variants that may inform efforts to promote PA and target the best type of PA for each individual. SUBJECTS/
methodsWe used data from the UK Biobank to perform the largest genome-wide association study of PA to date, using three measures based on self-report (n
resultsWe identified ten loci across all PA measures that were significant in both a basic and a fully adjusted model (p < 5 × 10
conclusionsThese results provide new insight into the genetic basis of habitual PA, and the genetic links connecting PA with other traits and diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.