ArticleThe ISME journal2018
Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 163 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
163 citing papers in PubMed, 5 syntheses or guidelines pooled it, 267 citations in OpenAlex.
- The Impact of Children's Dietary Habits on the Oral Microbiome: A Systematic Review.Nutrients · 2026Pooled it
- Pooled it
- Use of the oral microbiota as screening test to identify children at risk for caries development. A systematic review of longitudinal studies.European journal of oral sciences · 2026Pooled it
- Exploring Oral Microbiome in Healthy Infants and Children: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Is the mode of childbirth delivery linked to the prevalence of early childhood caries? A systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Pooled it
- Effects of silver diamine fluoride on oral bacteriome and mycobiome: a randomized clinical trial.BMC oral health · 2025Trial
- Effects of oropharyngeal administration of own mother's milk on oral microbial colonization in very low birth weight infants fed by gastric tube: A randomized controlled trial.Immunity, inflammation and disease · 2024Trial
- Personalized antibiotic selection in periodontal treatment improves clinical and microbiological outputs.Frontiers in cellular and infection microbiology · 2023Trial
- Child saliva microbiota and caries: a randomized controlled maternal education trial in rural Uganda.Scientific reports · 2022Trial
- Topic Application of the ProbioticFrontiers in cellular and infection microbiology · 2020Trial
- Temporal development of the oral microbiome and prediction of early childhood caries.Scientific reports · 2019Trial
- Nutritional status and its association with early childhood caries in Peruvian pre-schoolers aged 3-5 years: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Longitudinal Follow-Up of Gut and Salivary Microbiota in Children With Food Protein-Induced Enterocolitis Syndrome.Allergy · 2026Article
- Does permanent tooth eruption introduce periodontal pathogens? A preliminary study.Odontology · 2026Article
- The Oral-Gut-Brain Axis in Pediatric Populations: The Implications of Oral Dysbiosis for Systemic Inflammation and Neuroinflammation.Nutrients · 2026Review
- [Age-Related Changes in the Oral Microbiota].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Population-based characterisation of child and adolescent oral bacterial microbiomes.Microbiome · 2026Article
- Stool microbial composition is associated with recent and future diarrhea and fever events in breastfed Danish infants.mSystems · 2026Observational
- Protecting Newborns from Multidrug-Resistant Infections: The Emerging Role of Bacteriophages.Viruses · 2026Review
- Streptococcus dentisani and Streptococcus mutans in dental biofilm of preschoolers with and without early childhood caries: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
103 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Information on how the oral microbiome develops during early childhood and how external factors influence this ecological process is scarce. We used high-throughput sequencing to characterize bacterial composition in saliva samples collected at 3, 6, 12, 24 months and 7 years of age in 90 longitudinally followed children, for whom clinical, dietary and health data were collected. Bacterial composition patterns changed through time, starting with "early colonizers", including Streptococcus and Veillonella; other bacterial genera such as Neisseria settled after 1 or 2 years of age. Dental caries development was associated with diverging microbial composition through time. Streptococcus cristatus appeared to be associated with increased risk of developing tooth decay and its role as potential biomarker of the disease should be studied with species-specific probes. Infants born by C-section had initially skewed bacterial content compared with vaginally delivered infants, but this was recovered with age. Shorter breastfeeding habits and antibiotic treatment during the first 2 years of age were associated with a distinct bacterial composition at later age. The findings presented describe oral microbiota development as an ecological succession where altered colonization pattern during the first year of life may have long-term consequences for child´s oral and systemic health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.