ArticleNature2018
Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Predicted the P2RX7 rs3751143 polymorphism is associated with cancer risk: a meta-analysis and systematic review.Bioscience reports · 2021Pooled it
- Comparative analysis of conserved non-coding elements identifies gene regulatory networks rewired during the water-to-land transition in vertebrates.Biologia futura · 2026Article
- Early ultraviolet exposure disrupts late dorsal fin skeletal development in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish.Nature aging · 2026Article
- Tyrosinase-Deficient Skin Melanophore Lineage inInternational journal of molecular sciences · 2026Article
- 3DACS biomaterials science & engineering · 2026Review
- Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging.Nature aging · 2026Article
- Specific oncogene activation of the cell of origin in mucosal melanoma.Nature communications · 2025Article
- Enhancing the Performance of Si/GaNanomaterials (Basel, Switzerland) · 2025Article
- Widespread presence of bone marrow-like hematopoietic stem cell niche in invertebrate skeletons.Science advances · 2025Article
- 'Nomadic' Hematopoietic Stem Cells Navigate the Embryonic Landscape.Stem cell reviews and reports · 2025Review
- Establishment of reference intervals for complete blood count in healthy adults at different altitudes on the Western Sichuan Plateau.Frontiers in medicine · 2025Article
- Gelatin maleimide microgels for hematopoietic progenitor cell encapsulation.Journal of biomedical materials research. Part A · 2024Article
- Adaptive robustness through incoherent signaling mechanisms in a regenerative brain.Cell reports · 2024Article
- Redox pathways in melanoma.Advances in cancer research · 2024Review
- Article
- Effects of the environment on the evolution of the vertebrate urinary tract.Nature reviews. Urology · 2023Review
- Why are haematopoietic stem cells in the bone marrow: ontology recapitulates phylogeny.Leukemia · 2023Review
- Gadusol is a maternally provided sunscreen that protects fish embryos from DNA damage.Current biology : CB · 2023Article
- Disrupting Hedgehog signaling in melanocytes by SUFU knockout leads to ocular melanocytosis and anterior segment malformation.Disease models & mechanisms · 2023Article
Corrections and comments
- Commented on by
Authors and funding
14 authors at 11 institutions in 2 countries.
Friedrich G KappDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Julie R PerlinDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
Elliott J HagedornDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
John M GansnerDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Daniel E SchwarzUS Fish and Wildlife Service, Private John Allen National Fish Hatchery, Tupelo, MS, USA.
Lauren A O'ConnellDepartment of Biology, Stanford University, Stanford, CA, USA.
Nicholas S JohnsonUS Geological Survey, Great Lakes Science Center, Hammond Bay Biological Station, Millersburg, MI, USA.
Chris AmemiyaMolecular Cell Biology, University of California, Merced, CA, USA.
David E FisherCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Ute WölfleDepartment of Dermatology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Eirini TrompoukiDepartment of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Charlotte M NiemeyerDepartment of Pediatric Hematology and Oncology, Center for Pediatrics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Wolfgang DrieverDevelopmental Biology, Faculty of Biology, Centre for Biological Signalling Studies (BIOSS), Albert-Ludwigs-University of Freiburg, Freiburg, Germany.
Leonard I ZonDepartment of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. zon@enders.tch.harvard.edu.
Harvard Stem Cell Institute · USHarvard University · USUniversity of Freiburg · DEDana-Farber Cancer Institute · USHoward Hughes Medical Institute · USMax Planck Institute of Immunobiology and Epigenetics · DEStanford University · USUnited States Fish and Wildlife Service · USUnited States Geological Survey · USUniversity Medical Center Freiburg · DEUniversity of California, Merced · US
Funding
TRANSCRIPTION FACTOR GATA-1 IN TERMINAL ERYTHROID DEVELOPMENTP01HL032262 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI ORKIN, STUART H · 1985 to 2021
$38.9MTranscriptional mechanisms and melanomaP01CA163222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Liu · 2013 to 2026
$25.3MTranscriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David T Scadden · 2017 to 2026
$24.6MPhysician Scientist Training in Cancer ResearchT32CA009172 · NCI · DANA-FARBER CANCER INSTITUTE · PI Jennifer R Brown, James A. DeCaprio · 1985 to 2026
$17.1MCustomized stem cells for clinical application in blood disordersR24DK092760 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI COLLINS, JAMES J, DALEY, GEORGE Q · 2011 to 2018
$10.7MTRANSFUSION BIOLOGY AND MEDICINET32HL066987 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI JOHN P MANIS · 2001 to 2026
$10.2MThe MITF transcriptional network: melanoma risk and carcinogenesisR01AR043369 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID E FISHER · 1996 to 2026
$9.4MHuman Pluripotent Stem Cell and Progenitor Models of Cardiac and Blood DiseasesU01HL100001 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, ORKIN, STUART H · 2009 to 2015
$8.9MStem cells for therapeutics discovery in genetic blood disordersU01HL134812 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q, LIPTON, JEFFREY M · 2016 to 2022
$8.3MCancer Biology in the ZebrafishR01CA103846 · NCI · CHILDREN'S HOSPITAL BOSTON · PI ZON, LEONARD IRA · 2003 to 2022
$7.5MTraining Program in Molecular HematologyT32HL116324 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI NANCY BERLINER · 2013 to 2026
$7.4MProject-002U54DK110805 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI ORKIN, STUART H, ZON, LEONARD IRA · 2016 to 2020
$5.9MHoward Hughes Medical InstituteNCI NIH HHS P01 CA163222NCI NIH HHS R01 CA103846NCI NIH HHS T32 CA009172NCRR NIH HHS R24 RR017441NHLBI NIH HHS P01 HL032262NHLBI NIH HHS P01 HL131477NHLBI NIH HHS R01 HL048801NHLBI NIH HHS T32 HL066987NHLBI NIH HHS T32 HL116324NHLBI NIH HHS U01 HL100001NHLBI NIH HHS U01 HL134812NIAMS NIH HHS R01 AR043369NIDDK NIH HHS K01 DK111790NIDDK NIH HHS R01 DK053298NIDDK NIH HHS R24 DK092760NIDDK NIH HHS U54 DK110805
Abstract
Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour
Indexed as
Biological EvolutionAnimalsAquatic OrganismsCytoprotectionDNA DamageHematopoietic Stem CellsKidneyMelanocytesMutationPetromyzonPhylogenyPyrimidine DimersStem Cell NicheUltraviolet RaysZebrafishPyrimidine Dimers
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.