ArticleScientific reports2018
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 70 citations in OpenAlex.
- Assessing the persistence ofMicrobiology spectrum · 2026Article
- Environmental isolation ofVeterinary record open · 2025Article
- Sporothrix brasiliensis Atypical Dimorphism in Tissue.Mycopathologia · 2025Article
- A Novel In Vitro Host-Pathogen Model for Felis catus and Sporothrix Zoonotic Species Investigation.Journal of basic microbiology · 2025Article
- A novel approach for feline sporotrichosis pathogen detection based on loop-mediated isothermal amplification.Veterinary dermatology · 2025Article
- Application of Principal Component Analysis as a Prediction Model for Feline Sporotrichosis.Veterinary sciences · 2025Article
- Bilateral conjunctival sporotrichosis in a domestic cat: case report.Frontiers in veterinary science · 2025Article
- Neutrophil Oxidative Burst Profile Is Related to a Satisfactory Response to Itraconazole and Clinical Cure in Feline Sporotrichosis.Journal of fungi (Basel, Switzerland) · 2024Article
- Combination therapy of itraconazole and an acylhydrazone derivative (D13) for the treatment of sporotrichosis in cats.Microbiology spectrum · 2024Article
- A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis.Journal of fungi (Basel, Switzerland) · 2024Article
- Differential Recognition of Clinically RelevantJournal of fungi (Basel, Switzerland) · 2023Article
- Review
- Phenotypic and Genotypic Characterization and Antifungal Susceptibility ofJournal of fungi (Basel, Switzerland) · 2023Article
- Current Progress inJournal of fungi (Basel, Switzerland) · 2023Review
- Differential Recognition of Clinically RelevantJournal of fungi (Basel, Switzerland) · 2023Article
- Ethyl acetate fractions of Myrciaria floribunda, Ocotea pulchella, and Ocotea notata exhibit promising in vitro activity against Sporothrix brasiliensis isolates with low susceptibility to itraconazole.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Sporotrichosis Outbreak Due toJournal of fungi (Basel, Switzerland) · 2023Article
- Article
- Trends in Molecular Diagnostics and Genotyping Tools Applied for EmergingJournal of fungi (Basel, Switzerland) · 2022Review
- Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends.Journal of fungi (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats with sporotrichosis caused by S. brasiliensis. Fifty-two cats with skin lesions and a definitive diagnosis of sporotrichosis were treated with itraconazole for a maximum period of 36 weeks. The animals were submitted to clinical examination and two subsequent collections of samples from the same skin lesion for fungal diagnosis and histopathology, as well as serology for feline immunodeficiency (FIV) and leukaemia (FeLV) viruses. Thirty-seven (71%) cats were clinically cured. Nasal mucosa lesions and respiratory signs were associated with treatment failure. Cats coinfected with FIV/FeLV (n = 12) had a lower neutrophil count in the lesion. A high fungal load in skin lesions was linked to young age and treatment failure, as well as to a longer time of wound healing, poorly formed granulomas and fewer neutrophils, macrophages and lymphocytes in these lesions. These results indicate that itraconazole is effective, but nasal mucosal involvement, respiratory signs and high fungal loads in skin lesions are predictors of treatment failure that will assist in the development of better treatment protocols for cats.
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