Evidence map›Paper›PMID 29899403›Full record

ArticleNature communications2018

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.

Minh Binh Nguyen, Idan Cohen, Vinod Kumar, Zijian Xu, Carmit Bar, Katherine L Dauber-Decker, Pai-Chi Tsai, Pauline Marangoni, Ophir D Klein, Ya-Chieh Hsu and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  5. Development and regeneration of Merkel cells.Current topics in developmental biology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Minh Binh NguyenBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.
Idan CohenBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.
Vinod KumarDevelopmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland.
Zijian XuNational Institute of Biological Sciences, Beijing, 102206, China.
Carmit BarBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.
Katherine L Dauber-DeckerBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA.
Pai-Chi TsaiDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, MA, 02138, USA.
Pauline MarangoniDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA, 94143, USA.
Ophir D KleinDepartment of Orofacial Sciences and Program in Craniofacial Biology, University of California San Francisco, San Francisco, CA, 94143, USA.ORCID http://orcid.org/0000-0002-6254-7082
Ya-Chieh HsuDepartment of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, MA, 02138, USA.
Ting ChenNational Institute of Biological Sciences, Beijing, 102206, China.
Marja L MikkolaDevelopmental Biology Program, Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland.
Elena EzhkovaBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USA. elena.ezhkova@mssm.edu.ORCID http://orcid.org/0000-0002-5524-2344
Icahn School of Medicine at Mount Sinai · USHarvard University · USNational Institute of Biological Sciences, Beijing · CNUniversity of California, San Francisco · USUniversity of Helsinki · FI

Funding

Harnessing natural stem cell-based strategies for mammalian dental renewalR35DE026602 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KLEIN, OPHIR D · 2016 to 2023
$8.0M
Toward understanding the molecular mechanisms of Merkel cell fate determinationR01AR063724 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EZHKOVA, ELENA · 2012 to 2021
$4.2M
Interdependence of lineages within the mammalian skinR01AR070825 · NIAMS · HARVARD UNIVERSITY · PI HSU, YA-CHIEH · 2016 to 2020
$1.9M
Interdisciplinary Training in Systems and Developmental Biology and Birth DefectsT32HD075735 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JABS, ETHYLIN WANG · 2013 to 2022
$1.8M
NIAMS NIH HHS R01 AR063724NIAMS NIH HHS R01 AR070825NICHD NIH HHS T32 HD075735NIDCR NIH HHS R35 DE026602
6 · The paper itself

Abstract

Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis around primary hairs. While it has been shown that Merkel cells are skin epithelial cells, the progenitor cell population that gives rise to these cells is unknown. Here, we show that during embryogenesis, SOX9-positive (+) cells inside hair follicles, which were previously known to give rise to hair follicle stem cells (HFSCs) and cells of the hair follicle lineage, can also give rise to Merkel Cells. Interestingly, while SOX9 is critical for HFSC specification, it is dispensable for Merkel cell formation. Conversely, FGFR2 is required for Merkel cell formation but is dispensable for HFSCs. Together, our studies uncover SOX9(+) cells as precursors of Merkel cells and show the requirement for FGFR2-mediated epithelial signalling in Merkel cell specification.

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCell LineageEmbryonic Stem CellsFemaleGene Knockout TechniquesGreen Fluorescent ProteinsHair FollicleHedgehog ProteinsLIM-Homeodomain ProteinsMaleMerkel CellsMiceMice, KnockoutMice, TransgenicModels, BiologicalAtoh1 protein, mouseBasic Helix-Loop-Helix ProteinsFgfr2 protein, mouseGreen Fluorescent ProteinsHedgehog ProteinsLhx2 protein, mouseLIM-Homeodomain ProteinsNfatc1 protein, mouseNFATC Transcription FactorsReceptor, Fibroblast Growth Factor, Type 2Shh protein, mouseSox9 protein, mouseSOX9 Transcription FactorTranscription Factors

Identifiers

PMID29899403
PMCPMC5998134
OpenAlexW2807413787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.