Evidence map›Paper›PMID 29899382›Full record

ArticleCell death and differentiation2019

Constitutive IP

Mart Bittremieux, Rita M La Rovere, Haidar Akl, Claudio Martines, Kirsten Welkenhuyzen, Kathia Dubron, Myriam Baes, Ann Janssens, Peter Vandenberghe, Luca Laurenti and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Cell death and differentiation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Mitochondria-ER crosstalk via MAMS: Bridging cellular homeostasis and cancer progression.Apoptosis : an international journal on programmed cell death · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. IP3R2-mediated CaCell death discovery · 2024
    Article
  8. Article
  9. Article
  10. Sustained IP3-linked CaFrontiers in cell and developmental biology · 2023
    Article
  11. Article
  12. Bcl-xL acts as an inhibitor of IPCell death and differentiation · 2022
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Balancing ER-Mitochondrial CaTrends in cell biology · 2021
    Review
  18. Mitochondrial CaCells · 2021
    Review
  19. IPProgress in molecular and subcellular biology · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 5 countries.

Mart BittremieuxLab. Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine and Leuven Kanker Instituut, KU Leuven, Leuven, Belgium.
Rita M La RovereLab. Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine and Leuven Kanker Instituut, KU Leuven, Leuven, Belgium.
Haidar AklLab. Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine and Leuven Kanker Instituut, KU Leuven, Leuven, Belgium.
Claudio MartinesMolecular Hematology Unit, ICGEB, Trieste, Italy.
Kirsten WelkenhuyzenLab. Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine and Leuven Kanker Instituut, KU Leuven, Leuven, Belgium.
Kathia DubronLab. Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine and Leuven Kanker Instituut, KU Leuven, Leuven, Belgium.
Myriam BaesCell Metabolism, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Ann JanssensDepartment of Hematology, UZ Leuven, Leuven, Belgium.
Peter VandenbergheDepartment of Hematology, UZ Leuven, Leuven, Belgium.
Luca LaurentiUniversità Cattolica del Sacro Cuore, Fondazione Policlinico A. Gemelli, Rome, Italy.
Katja RietdorfSchool of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK.
Giampaolo MorcianoDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, Italy.
Paolo PintonDepartment of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and LTTA center, University of Ferrara, Ferrara, Italy.ORCID http://orcid.org/0000-0001-7108-6508
Katsuhiko MikoshibaThe Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, Wako, Saitama, Japan.
Martin D BootmanSchool of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK.ORCID http://orcid.org/0000-0002-6447-3451
Dimitar G EfremovMolecular Hematology Unit, ICGEB, Trieste, Italy.
Humbert De SmedtLab. Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine and Leuven Kanker Instituut, KU Leuven, Leuven, Belgium.
Jan B ParysLab. Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine and Leuven Kanker Instituut, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-3591-4967
Geert BultynckLab. Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine and Leuven Kanker Instituut, KU Leuven, Leuven, Belgium. geert.bultynck@kuleuven.be.ORCID http://orcid.org/0000-0002-5968-4828
KU Leuven · BEInternational Centre for Genetic Engineering and Biotechnology · ITThe Open University · GBUniversitair Ziekenhuis Leuven · BEUniversity of Ferrara · ITLebanese University · LBRIKEN Center for Brain Science · JPUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-apoptotic Bcl-2 proteins are upregulated in different cancers, including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL), enabling survival by inhibiting pro-apoptotic Bcl-2-family members and inositol 1,4,5-trisphosphate (IP

Indexed as

Amino Acid SequenceApoptosisCalciumCell Line, TumorHumansInositol 1,4,5-Trisphosphate ReceptorsLymphoma, Large B-Cell, DiffusePeptidesProto-Oncogene Proteins c-bcl-2Signal TransductionTransfectionBCL2 protein, humanBIRD-2 peptideCalciumInositol 1,4,5-Trisphosphate ReceptorsPeptidesProto-Oncogene Proteins c-bcl-2

Identifiers

PMID29899382
PMCPMC6370760
OpenAlexW2808014375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.