Evidence map›Paper›PMID 29899355›Full record

ArticleScientific reports2018

Long-term outcomes of kidney transplant recipients with end-stage kidney disease attributed to presumed/advanced glomerulonephritis or unknown cause.

Wai H Lim, Germaine Wong, Stephen P McDonald, Aron Chakera, Grant Luxton, Nicole M Isbel, Helen L Pilmore, Tom Barbour, Peter Hughes, Steven J Chadban

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Observational
  2. Better kidney allograft survival despite higher-risk donor and recipient characteristics between 1995 and 2014.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Recurrent andFrontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Wai H LimDepartment of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Australia. wai.lim@health.wa.gov.au.
Germaine WongAustralia and New Zealand Dialysis and Transplant Registry, Adelaide, Australia.
Stephen P McDonaldAustralia and New Zealand Dialysis and Transplant Registry, Adelaide, Australia.
Aron ChakeraDepartment of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Australia.ORCID 0000-0003-3369-4187
Grant LuxtonDepartment of Renal Medicine, Prince of Wales Hospital, Sydney, Australia.
Nicole M IsbelDepartment of Nephrology, Princess Alexandra Hospital, Brisbane, Australia.
Helen L PilmoreRenal Unit, Auckland Hospital & Department of Medicine, Auckland University, Auckland, New Zealand.
Tom BarbourDepartment of Nephrology, Royal Melbourne Hospital and Department of Medicine, University of Melbourne, Melbourne, Australia.
Peter HughesDepartment of Nephrology, Royal Melbourne Hospital and Department of Medicine, University of Melbourne, Melbourne, Australia.
Steven J ChadbanAustralia and New Zealand Dialysis and Transplant Registry, Adelaide, Australia.
The Royal Melbourne Hospital · AUThe University of Sydney · AUAuckland City Hospital · NZAustralia and New Zealand Dialysis and Transplant Registry · AUGovernment of Western Australia Department of Health · AUPrince of Wales Hospital · AUPrincess Alexandra Hospital · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People with biopsy-proven glomerulonephritis (GN) as their cause of end-stage kidney disease (ESKD) who undergo kidney transplantation incur significant risk of recurrent GN-related graft failure, but the risk in recipients with ESKD where GN was suspected but not biopsy proven (presumed/advanced GN) and when the cause of ESKD is unknown remains uncertain. Using the Australia and New Zealand Dialysis and Transplant registry, we examined the associations between primary kidney transplant recipients whose ESKD was attributed to: 1) commonly-recurring GN (i.e. IgA nephropathy, membranoproliferative GN, focal segmental glomerulosclerosis and membranous GN), 2) presumed/advanced GN, and 3) cause of ESKD unknown (uESKD) and GN-related graft failure using adjusted competing risk models. Of 5258 recipients followed for a median of 8 years, 3539 (67.3%) had commonly-recurring GN, 1195 (22.7%) presumed/advanced GN, and 524 (10.0%) uESKD. Compared to recipients with commonly-recurring GN, recipients with presumed/advanced GN or uESKD experienced a low incidence of GN-related graft failure (<1%) and a lower hazard of GN-related graft failure (adjusted sub-distribution hazard ratio [HR] 0.28 [95%CI 0.15-0.54,p < 0.001] and 0.20 [95%CI 0.06-0.64,p = 0.007], respectively). People with ESKD attributed to either presumed/advanced GN or unknown cause face a very low risk of graft failure secondary to GN recurrence after transplantation.

Indexed as

AdultAustraliaFemaleGlomerulonephritisGraft RejectionHumansIncidenceKaplan-Meier EstimateKidney Failure, ChronicKidney TransplantationMaleMiddle AgedNew ZealandRisk FactorsTransplant Recipients

Identifiers

PMID29899355
PMCPMC5998026
OpenAlexW2805962611

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.