ReviewInternational journal of molecular sciences2018
Recent Approaches to the Manufacturing of Biomimetic Multi-Phasic Scaffolds for Osteochondral Regeneration.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Implantation and Analysis of a Biphasic Bioinspired Osteochondral Chitosan Construct in a Large Animal Model.ACS biomaterials science & engineering · 2026Article
- Biomimetic Strategies for Bone Regeneration: Smart Scaffolds and Multiscale Cues.Biomimetics (Basel, Switzerland) · 2025Review
- Evaluation of the efficacy of a double-layered and single-layered synthetic scaffold for the treatment of knee osteochondral defects - an experimental study.Journal of orthopaedic surgery and research · 2025Article
- Investigation of decellularized live hyaline cartilage graft material for efficient treatment of knee cartilage defects.RSC advances · 2025Article
- Tomographic Assessment of Bone Regeneration in Osteochondral Lesion Treated with Various Biomaterials in a Sheep Model Study.Journal of functional biomaterials · 2025Article
- Engineered Osteochondral Scaffolds with Bioactive Cartilage Zone for Enhanced Articular Cartilage Regeneration.Annals of biomedical engineering · 2025Article
- A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration.Biomaterials and biosystems · 2024Article
- Full-thickness osteochondral defect repair using a biodegradable bilayered scaffold of porous zinc and chondroitin sulfate hydrogel.Bioactive materials · 2024Article
- Biomimetic Bilayered Scaffolds for Tissue Engineering: From Current Design Strategies to Medical Applications.Advanced healthcare materials · 2023Review
- Article
- Corncob Cellulose Scaffolds: A New Sustainable Temporary Implant for Cartilage Replacement.Journal of functional biomaterials · 2022Article
- Fabrication and Characterization of Bioactive Gelatin-Alginate-Bioactive Glass Composite Coatings on Porous Titanium Substrates.ACS applied materials & interfaces · 2022Article
- In vivo evaluation of additively manufactured multi-layered scaffold for the repair of large osteochondral defects.Bio-design and manufacturing · 2022Article
- Osteochondral tissue engineering: Perspectives for clinical application and preclinical development.Journal of orthopaedic translation · 2021Review
- A case report of femoral head fracture with osteochondral lesion treated by osteosynthesis and biomimetic scaffold: 2-year clinical and radiological follow-up.Journal of experimental orthopaedics · 2021Article
- Autologous chondrocytes versus filtered bone marrow mesenchymal stem/stromal cells for knee cartilage repair-a prospective study.International orthopaedics · 2021Article
- Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies.Journal of functional biomaterials · 2021Review
- Scaffold-Dependent Mechanical and Architectural Cues Guide Osteochondral Defect HealingFrontiers in bioengineering and biotechnology · 2021Article
- Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration.Regenerative biomaterials · 2020Review
- 3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications.Journal of materials science. Materials in medicine · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cartilage lesions of the knee are common disorders affecting people of all ages; as the lesion progresses, it extends to the underlying subchondral bone and an osteochondral defect appears. Osteochondral (OC) tissue compromises soft cartilage over hard subchondral bone with a calcified cartilage interface between these two tissues. Osteochondral defects can be caused by numerous factors such as trauma and arthritis. Tissue engineering offers the possibility of a sustainable and effective treatment against osteochondral defects, where the damaged tissue is replaced with a long-lasting bio-manufactured replacement tissue. This review evaluates both bi-phasic and multi-phasic scaffold-based approaches of osteochondral tissue regeneration, highlighting the importance of having an interface layer between the bone and cartilage layer. The significance of a biomimetic approach is also evidenced and shown to be more effective than the more homogenous design approach to osteochondral scaffold design. Recent scaffold materials and manufacturing techniques are reviewed as well as the current clinical progress with osteochondral regeneration scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.