Evidence map›Paper›PMID 29899038›Full record

ArticleThorax2018

Secondhand smoke exposure and asthma outcomes among African-American and Latino children with asthma.

Andreas M Neophytou, Sam S Oh, Marquitta J White, Angel C Y Mak, Donglei Hu, Scott Huntsman, Celeste Eng, Denise Serebrisky, Luisa N Borrell, Harold J Farber and 15 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Racial/ethnic discrimination and racial trauma: Concurrent evaluation among Black adults who smoke in the United States.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Assessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children.The journal of allergy and clinical immunology. In practice · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Asthma epidemiology and risk factors.Seminars in immunopathology · 2020
    Review
  18. Article
  19. Article
  20. Assessment of Respiratory Health Symptoms and Asthma in Children near a Drying Saline Lake.International journal of environmental research and public health · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 2 countries.

Andreas M NeophytouDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Sam S OhDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Marquitta J WhiteDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Angel C Y MakDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Donglei HuDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Scott HuntsmanDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Celeste EngDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Denise SerebriskyPediatric Pulmonary Division, Jacobi Medical Center, Bronx, New York, USA.
Luisa N BorrellDepartment of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York City, New York, USA.
Harold J FarberDepartment of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.
Kelley MeadeDepartment of Pediatrics, Children's Hospital and Research Center, Oakland, California, USA.
Adam DavisDepartment of Pediatrics, Children's Hospital and Research Center, Oakland, California, USA.
Pedro C AvilaFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Shannon M ThyneDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
William Rodríguez-CintrónVeterans Caribbean Health Care System, San Juan, Puerto Rico.
José R Rodríguez-SantanaCentro de Neumología Pediátrica, San Juan, Puerto Rico.
Rajesh KumarDivision of Allergy and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Emerita Brigino-BuenaventuraDepartment of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, California, USA.
Saunak SenDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Michael A LenoirBay Area Pediatrics, Oakland, California, USA.
L Keoki WilliamsDepartment of Internal Medicine, Henry Ford Health System, Detroit, Michigan, USA.
Neal L BenowitzDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
John R BalmesDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Ellen A EisenDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USUniversity of California, Berkeley · USLurie Children's Hospital · USCentro de Neumologia Pediatrica · PRCity University of New York · USHenry Ford Health System · USJacobi Medical Center · USKaiser Permanente Vallejo Medical Center · USKIPP Bay Area Schools · USTexas Children's Hospital · USUniversity of California, Los Angeles · USUniversity of Tennessee Health Science Center · USVA Caribbean Healthcare System · PR

Funding

The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2012 to 2016
$6.4M
Gene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4M
Transcriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1M
PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMAR01AI079139 · NIAID · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2009 to 2013
$3.9M
Genes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8M
Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed PopulationsR01HL118267 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WILLIAMS, KEOKI · 2014 to 2017
$2.9M
Gene-Environment Analyses of Early Life Exposures and Asthma in Ethnically Diverse ChildrenR21ES024844 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ, GAUDERMAN, WILLIAM JAMES · 2015 to 2017
$509k
Integrative Genetics and Genomics of Obese-Asthma in Minority ChildrenK01HL140218 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WHITE, MARQUITTA · 2018 to 2020
$457k
Air pollution exposures and children's health: mediation and interaction in a counterfactual frameworkK99ES027511 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NEOPHYTOU, ANDREAS · 2017 to 2018
$182k
NHLBI NIH HHS K01 HL140218NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R01 HL135156NIAID NIH HHS R01 AI079139NIEHS NIH HHS K99 ES027511NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD010443
6 · The paper itself

Abstract

backgroundSecondhand smoke (SHS) exposures have been linked to asthma-related outcomes but quantitative dose-responses using biomarkers of exposure have not been widely reported.

objectivesAssess dose-response relationships between plasma cotinine-determined SHS exposure and asthma outcomes in minority children, a vulnerable population exposed to higher levels of SHS and under-represented in the literature.

methodsWe performed analyses in 1172 Latino and African-American children with asthma from the mainland USA and Puerto Rico. We used logistic regression to assess relationships of cotinine levels ≥0.05 ng/mL with asthma exacerbations (defined as asthma-related hospitalisations, emergency room visits or oral steroid prescription) in the previous year and asthma control. The shape of dose-response relationships was assessed using a continuous exposure variable in generalised additive logistic models with penalised splines.

resultsThe OR for experiencing asthma exacerbations in the previous year for cotinine levels ≥0.05 ng/mL, compared with <0.05 ng/mL, was 1.40 (95% CI 1.03 to 1.89), while the OR for poor asthma control was 1.53 (95% CI 1.12 to 2.13). Analyses for dose-response relationships indicated increasing odds of asthma outcomes related with increasing exposure, even at cotinine levels associated with light SHS exposures.

conclusionsExposure to SHS was associated with higher odds of asthma exacerbations and having poorly controlled asthma with an increasing dose-response even at low levels of exposure. Our results support the conclusion that there are no safe levels of SHS exposures.

Indexed as

Black or African AmericanHispanic or LatinoAdolescentAsthmaChildFemaleHumansIncidenceMaleRisk AssessmentRisk FactorsTobacco Smoke PollutionUnited StatesYoung AdultTobacco Smoke Pollutionasthma epidemiologytobacco and the lung

Identifiers

PMID29899038
PMCPMC6225993
OpenAlexW2807950373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.