ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- A comprehensive EEG dataset of laser-evoked potentials for pain research.Scientific data · 2025Article
- Neural mechanisms underlying reduced nocifensive sensitivity in autism-associated Shank3 mutant dogs.Molecular psychiatry · 2025Article
- Low-Intensity Focused Ultrasound to the Human Dorsal Anterior Cingulate Attenuates Acute Pain Perception and Autonomic Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Deciphering Authentic Nociceptive Thalamic Responses in Rats.Research (Washington, D.C.) · 2024Article
- Distinct neocortical mechanisms underlie human SI responses to median nerve and laser-evoked peripheral activation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Pain-related reorganization in the primary somatosensory cortex of patients with postherpetic neuralgia.Human brain mapping · 2022Article
- From nociception to pain perception, possible implications of astrocytes.Frontiers in cellular neuroscience · 2022Article
- 3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects.Science advances · 2021Article
- A modality selective effect of functional laterality in pain detection sensitivity.Scientific reports · 2021Article
- Waves of Change: Brain Sensitivity to Differential, not Absolute, Stimulus Intensity is Conserved Across Humans and Rats.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Aerobic Exercise Attenuates Pain Sensitivity: An Event-Related Potential Study.Frontiers in neuroscience · 2021Article
- Intracortical Localization of a Promising Pain Biomarker.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Cross-Species Investigation on Resting State Electroencephalogram.Brain topography · 2019Article
- Music Reduces Pain Unpleasantness: Evidence from an EEG Study.Journal of pain research · 2019Article
- The search for pain biomarkers in the human brain.Brain : a journal of neurology · 2018Review
- Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
There is now compelling evidence that selective stimulation of Aδ nociceptors eliciting first pain evokes robust responses in the primary somatosensory cortex (S1). In contrast, whether the C-fiber nociceptive input eliciting second pain has an organized projection to S1 remains an open question. Here, we recorded the electrocortical responses elicited by nociceptive-specific laser stimulation of the four limbs in 202 humans (both males and females, using EEG) and 12 freely moving rats (all males, using ECoG). Topographical analysis and source modeling revealed in both species, a clear gross somatotopy of the unmyelinated C-fiber input within the S1 contralateral to the stimulated side. In the human EEG, S1 activity could be isolated as an early-latency negative deflection (C-N1 wave peaking at 710-730 ms) after hand stimulation, but not after foot stimulation because of the spatiotemporal overlap with the subsequent large-amplitude supramodal vertex waves (C-N2/P2). In contrast, because of the across-species difference in the representation of the body surface within S1, S1 activity could be isolated in rat ECoG as a C-N1 after both forepaw and hindpaw stimulation. Finally, we observed a functional dissociation between the generators of the somatosensory-specific lateralized waves (C-N1) and those of the supramodal vertex waves (C-N2/P2), indicating that C-fiber unmyelinated input is processed in functionally distinct somatosensory and multimodal cortical areas. These findings demonstrated that C-fiber input conveys information about the spatial location of noxious stimulation across the body surface, a prerequisite for deploying an appropriate defensive motor repertoire.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.