Evidence map›Paper›PMID 29899032›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin.

Joseph Santos-Sacchi, Winston Tan

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
7.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 88 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Amplification through local critical behavior in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Frontiers in audiology and otology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
  12. The Remarkable Outer Hair Cell: Proceedings of a Symposium in Honour of W. E. Brownell.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
  13. Prestin's fast motor kinetics is essential for mammalian cochlear amplification.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. A parametric blueprint for optimum cochlear outer hair cell design.Journal of the Royal Society, Interface · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Joseph Santos-SacchiDepartment of Surgery (Otolaryngology), joseph.santos-sacchi@yale.edu.ORCID 0000-0002-8274-7751
Winston TanDepartment of Surgery (Otolaryngology).
Universidade Católica de Santos · BR

Funding

MEMBRANES PROPERTIES OF CELLS COMPRISING THE OHC SYSTEMR01DC000273 · NIDCD · YALE UNIVERSITY · PI SANTOS-SACCHI, JOSEPH R · 1989 to 2015
$6.8M
Membrane properties of the OHC systemR01DC016318 · NIDCD · YALE UNIVERSITY · PI DHASAKUMAR S NAVARATNAM, JOSEPH R SANTOS-SACCHI · 2017 to 2026
$6.7M
Structural correlates of prestin activity.R01DC008130 · NIDCD · YALE UNIVERSITY · PI NAVARATNAM, DHASAKUMAR S, SANTOS-SACCHI, JOSEPH R · 2007 to 2021
$6.1M
NIDCD NIH HHS R01 DC000273NIDCD NIH HHS R01 DC008130NIDCD NIH HHS R01 DC016318
6 · The paper itself

Abstract

The voltage-dependent protein SLC26a5 (prestin) underlies outer hair cell electromotility (eM), which is responsible for cochlear amplification in mammals. The electrical signature of eM is a bell-shaped nonlinear capacitance (NLC), deriving from prestin sensor-charge (Q

Indexed as

AnimalsAuditory PerceptionFemaleGuinea PigsHair Cells, Auditory, OuterKineticsMaleMechanotransduction, CellularMiceMolecular Motor ProteinsProteinsMolecular Motor ProteinsPres protein, Cavia porcellusPres protein, mouseProteinscapacitancecochlear amplificationelectromotilitymembrane proteinsouter hair cellsensor charge

Identifiers

PMID29899032
PMCPMC6001036
OpenAlexW2803652518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.