Evidence map›Paper›PMID 29899024›Full record

ArticleScience translational medicine2018

A live vaccine rapidly protects against cholera in an infant rabbit model.

Troy P Hubbard, Gabriel Billings, Tobias Dörr, Brandon Sit, Alyson R Warr, Carole J Kuehl, Minsik Kim, Fernanda Delgado, John J Mekalanos, Joseph A Lewnard and 1 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 67 citations in OpenAlex.

  1. Trial
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  10. Frontiers in medicine · 2023
    Review
  11. A polyvalent multiepitope protein cross-protects againstProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Diagnosis, Management, and Future Control of Cholera.Clinical microbiology reviews · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. A Strategy for the Rapid Development of a SafeInternational journal of molecular sciences · 2021
    Article
  18. Article
  19. Article
  20. An Update on Cholera Immunity and Current and Future Cholera Vaccines.Tropical medicine and infectious disease · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Troy P HubbardDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2239-9158
Gabriel BillingsDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-3330-8023
Tobias DörrDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-3283-9161
Brandon SitDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2378-3039
Alyson R WarrDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1151-0108
Carole J KuehlDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9608-5533
Minsik KimDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-4133-5600
Fernanda DelgadoDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-9064-7737
John J MekalanosDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2792-9293
Joseph A LewnardCenter for Communicable Disease Dynamics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-8505-8839
Matthew K WaldorDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. mwaldor@research.bwh.harvard.edu.ORCID 0000-0003-1843-7000
Brigham and Women's Hospital · USCenter for Disease Dynamics, Economics & Policy · USHarvard University · US

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
Genetic Analysis of Toxinogenesis in Vibrio CholeraeR01AI018045 · NIAID · HARVARD MEDICAL SCHOOL · PI MEKALANOS, JOHN JOSEPH · 2009 to 2018
$6.7M
Molecular Biology and Virulence of CTX PhageR37AI042347 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WALDOR, MATTHEW K · 2008 to 2017
$3.8M
Genetic Analysis of Vibrio parahaemolyticus PathogenicityF31AI120665 · NIAID · HARVARD MEDICAL SCHOOL · PI HUBBARD, TROY PATRICK · 2015 to 2017
$96k
Howard Hughes Medical InstituteNIAID NIH HHS F31 AI120665NIAID NIH HHS R01 AI018045NIAID NIH HHS R01 AI042347NIAID NIH HHS R37 AI042347
6 · The paper itself

Abstract

Outbreaks of cholera, a rapidly fatal diarrheal disease, often spread explosively. The efficacy of reactive vaccination campaigns-deploying

Indexed as

Adaptive ImmunityAnimalsCholeraDisease ProgressionKineticsModels, TheoreticalRabbitsVaccines, AttenuatedVaccines, Attenuated

Identifiers

PMID29899024
PMCPMC6500431
OpenAlexW2807722763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.