ArticleScience translational medicine2018
NEDD9 targets
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Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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84citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
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Who cites it
84 citing papers in PubMed, 123 citations in OpenAlex.
- Cellular crosstalk between endothelial and vascular smooth muscle cells via the BACH1/COL3A1 axis promotes vascular calcification in chronic kidney disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- LGMN regulates endothelial-to-mesenchymal transition via the p38 MAPK pathway to promote pulmonary fibrosis.Functional & integrative genomics · 2026Article
- Adaptation of mesenchymal stromal cells to culture on collagen-based bioscaffold.Journal of materials science. Materials in medicine · 2026Article
- Broiler Ascites Syndrome as a Potential Spontaneous Animal Model for Human Pulmonary Arterial Hypertension: A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Inhibition of CDK8 rescues impaired ischemic fracture healing.NPJ Regenerative medicine · 2026Article
- Comprehensive profiling of lactylation-associated genes in pulmonary hypertension through bulk and single-cell RNA sequencing integration.Respiratory research · 2026Article
- The Role of Exosomes in Pulmonary Hypertension: Mechanisms and Therapeutic Potential.International journal of nanomedicine · 2026Review
- Protein biomarkers in pulmonary arterial hypertension: advances, clinical relevance, and translational challenges.Journal of translational medicine · 2025Review
- Unsupervised feature extraction using deep learning empowers discovery of genetic determinants of the electrocardiogram.Genome medicine · 2025Article
- Article
- Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting.Nature communications · 2025Article
- Overexpression of Neural Precursor Cell Expressed Developmentally Downregulated 9 (NEDD9) reduces ox-LDL-induced Anoikis in atherosclerotic vascular endothelial cells.International journal of cardiology. Heart & vasculature · 2025Article
- Convergent evolution in high-altitude and marine mammals: Molecular adaptations to pulmonary fibrosis and hypoxia.Zoological research · 2024Article
- GTSE1-driven ZEB1 stabilization promotes pulmonary fibrosis through the epithelial-to-mesenchymal transition.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells.Nature metabolism · 2024Article
- Superenhancer-driven circRNA Myst4 involves in pulmonary artery smooth muscle cell ferroptosis in pulmonary hypertension.iScience · 2024Article
- Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells.bioRxiv : the preprint server for biology · 2024Article
- Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond.Hypertension (Dallas, Tex. : 1979) · 2024Review
- NKX2-5 regulates vessel remodeling in scleroderma-associated pulmonary arterial hypertension.JCI insight · 2024Article
- Single-cell RNA sequencing reveals critical modulators of extracellular matrix of penile cavernous cells in erectile dysfunction.Scientific reports · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
29 authors at 7 institutions in 3 countries.
Andriy O SamokhinDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-7268-8006
Thomas StephensDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Bradley M WertheimDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Rui-Sheng WangChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Sara O VargasDepartment of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.
Lai-Ming YungDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-3650-2980
Minwei CaoDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Marcel BrownDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-1553-5684
Elena AronsDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Paul B DieffenbachDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Jason G FewellCelsion Corporation, Lawrenceville, NJ 08648, USA.
Majed MatarCelsion Corporation, Lawrenceville, NJ 08648, USA.
Frederick P BowmanDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-8143-879X
Kathleen J HaleyDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
George A AlbaDepartment of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Stefano M MarinoDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Rahul KumarProgram in Translational Lung Research, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Ivan O RosasDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Aaron B WaxmanDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
William M OldhamDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-3029-4866
Dinesh KhannaDivision of Rheumatology, University of Michigan Scleroderma Program, Ann Arbor, MI 48109, USA.
Brian B GrahamProgram in Translational Lung Research, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-7541-2585
Sachiko SeoDepartment of Hematology and Oncology, National Cancer Research Center East, Kashiwa-shi, Chiba-ken 277-8577, Japan.ORCID 0000-0002-4308-2152
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-0372-7016
Paul B YuDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-2145-4944
Laura E FredenburghDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-7447-6453
Joseph LoscalzoDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Jane A LeopoldDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Bradley A MaronDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. bmaron@bwh.harvard.edu.ORCID 0000-0002-6784-764X
Brigham and Women's Hospital · USCelsion (United States) · USUniversity of Colorado Anschutz Medical Campus · USBoston Children's Hospital · USMassachusetts General Hospital · USNational Cancer Center Hospital East · JPScleroderma Foundation · US
Funding
Tissue AnalysesP01HL048743 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHEL, THOMAS · 1992 to 2014
$26.3MBoston Biomedical Innovation CenterU54HL119145 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLAN, DAVID E., LOSCALZO, JOSEPH · 2013 to 2021
$18.8MRESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9MPulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1MGPx-3 and Peroxide Flux in the Endothelial CellR37HL061795 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2007 to 2016
$4.3MTargeting FAK-NEDD9 protein-protein interaction to prevent focal adhesion assembly and vascular proliferation in pulmonary arterial hypertensionR01HL139613 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Sirano Dhe-Paganon, Bradley Maron · 2018 to 2026
$4.1MFunctions of thioredoxin reductases and their targetsR37GM065204 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI GLADYSHEV, VADIM N. · 2011 to 2020
$4.0MThe Phathophenotype Landscape of Complex DiseaseU01HL108630 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2011 to 2014
$2.7MMechanotransduction and YAP/TAZ Signaling in Pulmonary Arterial HypertensionR01HL137366 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PERRELLA, MARK A, TSCHUMPERLIN, DANIEL J. · 2018 to 2021
$2.7MHLS- Cyclic CAR peptide: a targeted therapy for pulmonary hypertensionR42HL132742 · NHLBI · VASCULAR BIOSCIENCES · PI YU, PAUL B · 2017 to 2019
$2.3MMolecular imaging of angiogenic activity in pulmonary arterial hypertensionR01HL131910 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI YU, PAUL B · 2016 to 2018
$2.3MFunctions of Mammalian Thioredoxin ReductasesR01GM065204 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GLADYSHEV, VADIM N. · 2002 to 2009
$2.2MNHLBI NIH HHS F32 HL131228NHLBI NIH HHS F32 HL139019NHLBI NIH HHS K08 HL111207NHLBI NIH HHS K08 HL128802NHLBI NIH HHS P01 HL048743NHLBI NIH HHS R01 HL114839NHLBI NIH HHS R01 HL131910NHLBI NIH HHS R01 HL137366NHLBI NIH HHS R01 HL139613NHLBI NIH HHS R24 HL123767NHLBI NIH HHS R37 HL061795NHLBI NIH HHS R42 HL132742NHLBI NIH HHS R56 HL131787NHLBI NIH HHS T32 HL007633NHLBI NIH HHS U01 HL108630NHLBI NIH HHS U01 HL125215NHLBI NIH HHS U54 HL119145NIAMS NIH HHS K24 AR063120NIAMS NIH HHS R01 AR070470NIGMS NIH HHS R01 GM065204NIGMS NIH HHS R37 GM065204
Abstract
Germline mutations involving small mothers against decapentaplegic-transforming growth factor-β (SMAD-TGF-β) signaling are an important but rare cause of pulmonary arterial hypertension (PAH), which is a disease characterized, in part, by vascular fibrosis and hyperaldosteronism (ALDO). We developed and analyzed a fibrosis protein-protein network (fibrosome) in silico, which predicted that the SMAD3 target neural precursor cell expressed developmentally down-regulated 9 (NEDD9) is a critical ALDO-regulated node underpinning pathogenic vascular fibrosis. Bioinformatics and microscale thermophoresis demonstrated that oxidation of Cys
Indexed as
Adaptor Proteins, Signal TransducingAnimalsCollagen Type IIIEndothelial CellsFemaleFibrosisHumansHypertension, PulmonaryLungMalePhosphoproteinsProtein BindingPulmonary ArteryRatsRats, Sprague-DawleySmad3 ProteinAdaptor Proteins, Signal TransducingCOL3A1 protein, humanCollagen Type IIINEDD9 protein, humanPhosphoproteinsSmad3 Protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.