Evidence map›Paper›PMID 29898965›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

B7-H4 Modulates Regulatory CD4

Joseph R Podojil, Ming-Yi Chiang, Igal Ifergan, Ronald Copeland, Linda N Liu, Sebastien Maloveste, Solomon Langermann, David Liebenson, Roumen Balabanov, Hongbo Chi and 3 more

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joseph R PodojilDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0002-5818-8515
Ming-Yi ChiangDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Igal IferganDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Ronald CopelandAmplimmune, Inc., Gaithersburg, MD 20877.
Linda N LiuAmplimmune, Inc., Gaithersburg, MD 20877.ORCID 0000-0002-4220-1076
Sebastien MalovesteAmplimmune, Inc., Gaithersburg, MD 20877.
Solomon LangermannAmplimmune, Inc., Gaithersburg, MD 20877.ORCID 0000-0002-9596-4931
David LiebensonDepartment of Neurology, Rush University, Chicago, IL 60612.
Roumen BalabanovDepartment of Neurology, Rush University, Chicago, IL 60612.
Hongbo ChiImmunology Department, St. Jude Children's Research Hospital, Memphis, TN 38105.
Lieping ChenDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06510.
Dario A A VignaliDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15262; and.ORCID 0000-0002-2771-5992
Stephen D MillerDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611; s-d-miller@northwestern.edu.ORCID 0000-0002-9556-0718

Funding

IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAER01NS026543 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MILLER, STEPHEN D · 1988 to 2016
$5.0M
PATHOGENESIS AND IMMUNOREGULATION OF PLP-INDUCED R-EAER01NS030871 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MILLER, STEPHEN D · 1993 to 2010
$3.4M
NINDS NIH HHS R01 NS026543NINDS NIH HHS R01 NS030871
6 · The paper itself

Abstract

The potent immune regulatory function of an agonistic B7-H4-Ig fusion protein (B7-H4Ig) has been demonstrated in multiple experimental autoimmune models; however, the identity of a functional B7-H4 receptor remained unknown. The biological activity of B7-H4 is associated with decreased inflammatory CD4

Indexed as

AnimalsCD4-Positive T-LymphocytesCells, CulturedFemaleForkhead Transcription FactorsHumansInflammationMacrophagesMiceMice, Inbred C57BLNeuropilin-1PTEN PhosphohydrolaseReceptors, Cell SurfaceSemaphorin-3ATumor MicroenvironmentV-Set Domain-Containing T-Cell Activation Inhibitor 1Forkhead Transcription FactorsNeuropilin-1Plxna4 protein, humanPTEN PhosphohydrolaseReceptors, Cell SurfaceSEMA3A protein, humanSemaphorin-3AV-Set Domain-Containing T-Cell Activation Inhibitor 1VTCN1 protein, human

Identifiers

PMID29898965
PMCPMC6894186

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.