ArticleGenome research2018
Human-specific features of spatial gene expression and regulation in eight brain regions.
Article in Genome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 100 citations in OpenAlex.
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- The Nodding syndrome cerebrospinal fluid proteome: a lens into neurodevelopmental failure consistent with environmentally triggeredFrontiers in molecular neuroscience · 2026Article
- Human CLOCK enhances neocortical function.Nature neuroscience · 2025Article
- Ecological Trait Differences Are Associated with Gene Expression in the Primary Visual Cortex of Primates.Genes · 2025Article
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- Long non-coding RNAs expression and regulation across different brain regions in primates.Scientific data · 2024Article
- Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder.Schizophrenia (Heidelberg, Germany) · 2024Article
- VAMP7j: A Splice Variant of Human VAMP7 That Modulates Neurite Outgrowth by Regulating L1CAM Transport to the Plasma Membrane.International journal of molecular sciences · 2023Article
- Integration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation.Cell death & disease · 2023Article
- Analysis of the brain transcriptome for substance-associated genes: An update on large-scale genome-wide association studies.Addiction biology · 2023Article
- Transcription, structure, and organoids translate time across the lifespan of humans and great apes.PNAS nexus · 2023Article
- Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes.Physiological reviews · 2023Review
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- Detection of orthologous exons and isoforms using EGIO.Bioinformatics (Oxford, England) · 2022Article
- Returning to basic principles to develop more effective treatments for central nervous system disorders.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Landscape of adenosine-to-inosine RNA recoding across human tissues.Nature communications · 2022Article
- Genomic approaches to trace the history of human brain evolution with an emerging opportunity for transposon profiling of ancient humans.Mobile DNA · 2021Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular maps of the human brain alone do not inform us of the features unique to humans. Yet, the identification of these features is important for understanding both the evolution and nature of human cognition. Here, we approached this question by analyzing gene expression and H3K27ac chromatin modification data collected in eight brain regions of humans, chimpanzees, gorillas, a gibbon, and macaques. An analysis of spatial transcriptome trajectories across eight brain regions in four primate species revealed 1851 genes showing human-specific transcriptome differences in one or multiple brain regions, in contrast to 240 chimpanzee-specific differences. More than half of these human-specific differences represented elevated expression of genes enriched in neuronal and astrocytic markers in the human hippocampus, whereas the rest were enriched in microglial markers and displayed human-specific expression in several frontal cortical regions and the cerebellum. An analysis of the predicted regulatory interactions driving these differences revealed the role of transcription factors in species-specific transcriptome changes, and epigenetic modifications were linked to spatial expression differences conserved across species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.