Evidence map›Paper›PMID 29898765›Full record

Trial reportArthritis research & therapy2018

Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study.

David B Bartlett, Leslie H Willis, Cris A Slentz, Andrew Hoselton, Leslie Kelly, Janet L Huebner, Virginia B Kraus, Jennifer Moss, Michael J Muehlbauer, Guillaume Spielmann and 3 more

2 registry-linked trialsOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arthritis research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 91 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 4 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02528344 nacompletednot on this map

The Effects of High-Intensity Interval Training on Inflammation in Adults With Rheumatoid Arthritis

TypeinterventionalSponsorDuke UniversityRan2015Enrolled12ConditionsRheumatoid ArthritisArmsHIIT
NCT06953648 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplantation (REMM-HIIT-HCT)

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2025 to 2030Enrolled126ConditionsHematopoietic Stem Cell Transplantation, Cardiorespiratory FitnessArmsHigh Intensity Interval Training
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 4 syntheses or guidelines pooled it, 167 citations in OpenAlex.

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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

David B BartlettDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. david.bartlett@duke.edu.
Leslie H WillisDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Cris A SlentzDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Andrew HoseltonDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Leslie KellyDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Janet L HuebnerDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Virginia B KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Jennifer MossDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Michael J MuehlbauerDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Guillaume SpielmannDepartment of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
William E KrausDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Janet M LordMRC-ARUK Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Kim M HuffmanDuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
Duke University · USLouisiana State University · USUniversity of Birmingham · GB

Funding

Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
Medical Research Council MR/K00414X/1Medical Research Council MR/P021220/1NCATS NIH HHS UL1 TR001117
6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and increased risk of opportunistic infection. Exercise training can improve the health of patients with RA and potentially improve immune function; however, information on the effects of high-intensity interval training (HIIT) in RA is limited. We sought to determine whether 10 weeks of a walking-based HIIT program would be associated with health improvements as measured by disease activity and aerobic fitness. Further, we assessed whether HIIT was associated with improved immune function, specifically antimicrobial/bacterial functions of neutrophils and monocytes.

methodsTwelve physically inactive adults aged 64 ± 7 years with either seropositive or radiographically proven (bone erosions) RA completed 10 weeks of high-intensity interval walking. Training consisted of 3 × 30-minute sessions/week of ten ≥ 60-second intervals of high intensity (80-90% VO

resultsDespite minimal body composition change, cardiorespiratory fitness increased by 9% (change in both relative and absolute aerobic capacity; p < 0.001), and resting blood pressure and heart rate were both reduced (both p < 0.05). Postintervention disease activity was reduced by 38% (DAS28; p = 0.001) with significant reductions in ESR and swollen joints as well as improved self-perceived health. Neutrophil migration toward CXCL-8 (p = 0.003), phagocytosis of Escherichia coli (p = 0.03), and ROS production (p < 0.001) all increased following training. The frequency of cluster of differentiation 14-positive (CD14

conclusionsWe report for the first time, to our knowledge, that a high-intensity interval walking protocol in older adults with stable RA is associated with reduced disease activity, improved cardiovascular fitness, and improved innate immune functions, indicative of reduced infection risk and inflammatory potential. Importantly, the exercise program was well tolerated by these patients.

trial registrationClinicalTrials.gov, NCT02528344 . Registered on 19 August 2015.

Indexed as

AgedArthritis, RheumatoidCytokinesEscherichia coliExercise TherapyFemaleHigh-Intensity Interval TrainingHumansImmunity, InnateMaleMiddle AgedNeutrophilsPhagocytosisPilot ProjectsSeverity of Illness IndexWalkingCytokinesDisease activityHigh-intensity interval exerciseInflammationInnate immunityRheumatoid arthritis

Identifiers

PMID29898765
PMCPMC6001166
OpenAlexW2808027513

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.