ArticleBehavioral and brain functions : BBF2018
Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM).
Article in Behavioral and brain functions : BBF, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Studying the Stress, Gene Expression, and Behavioral Changes Induced by Diazepam and Sertraline in a Zebrafish Model.Journal of applied toxicology : JAT · 2026Article
- E. Coli Nissle 1917 Attenuates Antibiotic Mediated Neurotoxicity Possibly Through Gut-Brain Axis in Zebrafish.Applied biochemistry and biotechnology · 2026Article
- Efficacy of Probiotic Escherichia coli Nissle 1917 in Counteracting Reserpine-induced Depression-like Symptoms and Neuroinflammation in Zebrafish.Indian journal of psychological medicine · 2026Article
- Neuroprotective effects of traditional Chinese medicine using zebrafish models - a review.Frontiers in pharmacology · 2026Review
- Zebrafish as a translational platform for investigating multi-organ pharmacological interactions of traditional Chinese medicine.Frontiers in pharmacology · 2026Review
- Lessons in cognition: A review of maze designs and procedures used to measure spatial learning in fish.Journal of fish biology · 2025Review
- Niosomal Bupropion: Exploring Therapeutic Frontiers through Behavioral Profiling.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Research on Xiaoyao Powder in the treatment of depression based on epigenetics and quality markers.Frontiers in neuroscience · 2023Review
- Advances in Zebrafish as a Comprehensive Model of Mental Disorders.Depression and anxiety · 2023Review
- Towards Modeling Anhedonia and Its Treatment in Zebrafish.The international journal of neuropsychopharmacology · 2022Article
- Elaborate the Mechanism of Ancient Classic Prescriptions (Erzhi Formula) in Reversing GIOP by Network Pharmacology Coupled with Zebrafish Verification.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- General Use of Chinese Herbal Products among Female Patients with Mastitis in Taiwan.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Research progress on classical traditional chinese medicine formula xiaoyaosan in the treatment of depression.Frontiers in pharmacology · 2022Review
- Association of Chinese herbal medicine use with the depression risk among the long-term breast cancer survivors: A longitudinal follow-up study.Frontiers in psychology · 2022Article
- A Reliable High-Throughput Screening Model for Antidepressant.International journal of molecular sciences · 2021Article
- Antidepressant and Anxiolytic-Like Effects of the Stem Bark Extract ofFrontiers in behavioral neuroscience · 2021Article
- DuplicatedGenes · 2020Article
- Behavioral and Brain Functions at 15.Behavioral and brain functions : BBF · 2020Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWith increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life. Fortunately, the Traditional Chinese Medicine Jia Wei Xiao Yao (JWXY) capsule is effective in reducing depression and improving cognitive behaviour.
methodsThe constituents of JWXY capsule were identified by ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry analyses. We analysed behaviours of depression-like zebrafish in the novel tank with an automatic 3D video-tracking system and conducted the colour preference test, as well detected physiological changes after sertraline and JWXY capsule treatments.
resultsBoth sertraline and JWXY capsule rescued the decreased locomotive behaviour and depression phenotype of zebrafish caused by reserpine. JWXY capsule especially improved the inhibited exploratory behaviour caused by reserpine. In addition, with the onset of depressive behaviour, zebrafish exhibited alterations in cognitive behaviour as indicated by colour preference changes. However, compared with sertraline, JWXY capsule was more efficaciously in rescuing this change in the colour preference pattern. Moreover, an increased level of cortisol, increased expression of tyrosine hydroxylase (TH) and decreased monoamine neurotransmitters, including serotonin (5-HT) and noradrenaline, were involved in the depressive behaviours. In addition, sertraline and JWXY capsule rescued the depressive phenotype and cognitive behaviour of zebrafish by altering the levels of endogenous cortisol and monoamine neurotransmitters.
conclusionsJWXY capsule was more effectively than sertraline in rescuing reserpine-induced depression and cognitive disorder in zebrafish. Potentially, our study can provide new insights into the clinical treatment of depression and the mechanism of action of JWXY capsule.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.