ArticleJournal of translational medicine2018
Identification of a low risk population for parametrial invasion in patients with early-stage cervical cancer.
Article in Journal of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Villoglandular adenocarcinoma of the uterine cervix: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2021Pooled it
- Preoperative prediction of parametrial invasion in early-stage cervical cancer: a radiomics nomogram fusing multi-parametric MRI and clinical biomarkers.Abdominal radiology (New York) · 2026Article
- Review
- Risk factors for parametrial invasion in early-stage cervical cancer: Toward less radical surgery.Turkish journal of obstetrics and gynecology · 2025Article
- Constructing and identifying an eighteen-gene tumor microenvironment prognostic model for non-small cell lung cancer.World journal of surgical oncology · 2024Article
- Prediction of recurrence risk factors in patients with early-stage cervical cancers by nomogram based on MRI handcrafted radiomics features and deep learning features: a dual-center study.Abdominal radiology (New York) · 2024Article
- Impact of therapeutic strategy on disease-free and overall survival of early-stage cervical cancer: Surgery alone versus preoperative radiation.Cancer reports (Hoboken, N.J.) · 2023Article
- What are the determinants of parametrial invasion in patients with early stage cervical cancer: A cross sectional study.Annals of medicine and surgery (2012) · 2022Article
- Correlation between Neutrophil-to-Lymphocyte Ratio and Pretreatment Magnetic Resonance Imaging and Their Predictive Significance in Cervical Carcinoma Patients Referred for Radiotherapy.Journal of oncology · 2022Article
- Does a pre-operative conization improve disease-free survival in early-stage cervical cancer?Archives of gynecology and obstetrics · 2021Article
- The feasibility ofCancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- Nomogram Predicting the Likelihood of Parametrial Involvement in Early-Stage Cervical Cancer: Avoiding Unjustified Radical Hysterectomies.Journal of clinical medicine · 2020Article
- Preoperative prediction of parametrial invasion in early-stage cervical cancer with MRI-based radiomics nomogram.European radiology · 2020Article
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Authors and funding
18 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have challenged radical procedures for less extensive surgery in selected patients with early-stage cervical cancer at low risk of parametrial invasion. Our objective was to identify a subgroup of patients at low risk of parametrial invasion among women having undergone surgical treatment.
methodsData of 1447 patients with cervical cancer treated between 1996 and 2016 were extracted from maintained databases of 10 French University hospitals. Patients with early-stage (IA2-IIA) disease treated by radical surgery including hysterectomy and trachelectomy, were selected for further analysis. The Kaplan-Meier method was used to estimate the survival distribution. A Cox proportional hazards model including all the parameters statistically significant in univariate analysis, was used to account for the influence of multiple variables.
resultsOut of the 263 patients included for analysis, on final pathology analysis 28 (10.6%) had parametrial invasion and 235 (89.4%) did not. Factors significantly associated with parametrial invasion on multivariate analysis were: age > 65 years, tumor > 30 mm in diameter measured by MRI, lymphovascular space invasion (LVSI) on pathologic analysis. Among the 235 patients with negative pelvic lymph nodes, parametrial disease was seen in only 7.6% compared with 30.8% of those with positive pelvic nodes (p < 0.001). In a subgroup of patients presenting tumors < 30 mm, negative pelvic status and no LVSI, the risk of parametrial invasion fell to 0.6% (1/173 patients).
conclusionOur analysis suggests that there is a subgroup of patients at very low risk of parametrial invasion, potentially eligible for less radical procedures.
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