ArticleBiomedical engineering online2018
Noninvasive assessment of age-related stiffness of crystalline lenses in a rabbit model using ultrasound elastography.
Article in Biomedical engineering online, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Evaluation of Changes in Ocular Tissue Elasticity Before and After Trabeculectomy Using Shear Wave Elastography.Journal of clinical medicine · 2026Article
- Quantitative fs-laser crystalline lens softening surgery towards presbyopia treatment based on optical coherence elastography.Biomedical optics express · 2025Article
- Mechanical Properties of Eye Lens Cortical and Nuclear Membranes and the Whole Lens.Investigative ophthalmology & visual science · 2025Article
- Comparative analysis of rodent lens morphometrics and biomechanical properties.Frontiers in ophthalmology · 2025Article
- Ocular biometry in rabbits using computed tomography.Veterinary ophthalmology · 2024Article
- Article
- Compound Acoustic Radiation Force Impulse Imaging of Bovine Eye by Using Phase-Inverted Ultrasound Transducer.Sensors (Basel, Switzerland) · 2024Article
- Tissue, cellular, and molecular level determinants for eye lens stiffness and elasticity.Frontiers in ophthalmology · 2024Review
- Storage-induced mechanical changes of porcine lenses assessed with optical coherence elastography and inverse finite element modeling.Frontiers in bioengineering and biotechnology · 2024Article
- Estimation of Crystalline Lens Material Properties From Patient Accommodation Data and Finite Element Models.Investigative ophthalmology & visual science · 2023Article
- Simultaneous Assessment of the Whole Eye Biomechanics Using Ultrasonic Elastography.IEEE transactions on bio-medical engineering · 2023Article
- Deep Tissue Characterization with Optical Coherence Elastography: A Comparison of Different Methods.Materials (Basel, Switzerland) · 2022Article
- Article
- EphA2 Affects Development of the Eye Lens Nucleus and the Gradient of Refractive Index.Investigative ophthalmology & visual science · 2022Article
- Mechanical properties of the high cholesterol-containing membrane: An AFM study.Biochimica et biophysica acta. Biomembranes · 2021Article
- Ultrasound elastography for evaluating stiffness of the human lens nucleus with aging: a feasibility study.International journal of ophthalmology · 2021Article
- In vivo ultraosound elastographic evaluation of the age-related change of human lens nuclear stiffness.BMC ophthalmology · 2020Article
- Multimodal quantitative optical elastography of the crystalline lens with optical coherence elastography and Brillouin microscopy.Biomedical optics express · 2020Article
- Ultrahigh-sensitive optical coherence elastography.Light, science & applications · 2020Article
- Noninvasive stiffness assessment of the human lens nucleus in patients with anisometropia using an ultrasound elastography system.International journal of ophthalmology · 2020Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe pathological or physiological changes of a crystalline lens directly affect the eye accommodation and transmittance, and then they increase the risk of presbyopia and cataracts for people in the middle and old age groups. There is no universally accepted quantitative method to measure the lens' mechanical properties in vivo so far. This study aims to investigate the possibility of assessing the age-related stiffness change of crystalline lens by acoustic-radiation-force-based ultrasound elastography (ARF-USE) in a rabbit model in vivo.
methodsThere were 13 New Zealand white rabbits that were divided into four groups and fed normally until they were 60 (n = 4), 90 (n = 2), 120 (n = 4), and 150 (n = 3) days old, respectively. An ARF-USE platform was built based on the Verasonics™ Vantage 256 system. The shear waves were excited and traced in the lens by a linear ultrasound probe after a rabbit was anaesthetized.
resultsThe average group velocities were 1.38 ± 0.2 m/s, 2.06 ± 0.3 m/s, 2.07 ± 0.29 m/s, and 2.30 ± 0.28 m/s, respectively, for the four groups of rabbits. The results shows that the group velocity has a strong correlation with the day age (r = 0.84, p < 1 × 10
conclusionThis study demonstrated that the group velocity measured by ARF-USE had a strong correlation with age-related stiffness in a rabbit model, suggesting that group velocity is a good biomarker to characterize the stiffness of a crystalline lens. This study also demonstrated the feasibility of using this USE technique to assess the mechanical properties of the lens in vivo for clinical or research purposes.
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