Evidence map›Paper›PMID 29898681›Full record

ArticleBMC infectious diseases2018

Mitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(-) mothers.

Meng Zhuo Cao, Yan Hua Wu, Si Min Wen, Yu Chen Pan, Chong Wang, Fei Kong, Chuan Wang, Jun Qi Niu, Jie Li, Jing Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Meng Zhuo CaoDepartment of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100020, China.
Yan Hua WuDivision of Clinical Research, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Si Min WenDivision of Clinical Research, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Yu Chen PanDivision of Clinical Research, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Chong WangDepartment of Hepatology, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Fei KongDepartment of Hepatology, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Chuan WangDivision of Clinical Research, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Jun Qi NiuDepartment of Hepatology, The First Hospital of Jilin University, Changchun, 130021, Jilin, China. junqiniu@aliyun.com.
Jie LiDepartment of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100020, China. jieli69@263.net.
Jing JiangDivision of Clinical Research, The First Hospital of Jilin University, Changchun, 130021, Jilin, China. jiangjing19702000@jlu.edu.cn.ORCID 0000-0001-9714-9255
Jilin University · CNPeking University · CN

Funding

China Hepatitis Prevention Foundation Project (TIAN QING Liver Disease foundation) TQGB20140137Science and Technology Development Program of Jilin Province 20150414014GHThe Twelfth National Five-Year Key Projects in infectious diseases of China 2012ZX10002001-001
6 · The paper itself

Abstract

backgroundInfants born to hepatitis B surface antigen (HBsAg) positive mothers are at a higher risk for Hepatitis B virus (HBV) infection. Host genetic background plays an important role in determining the strength of immune response to vaccination. We conducted this study to investigate the association between Tumor necrosis factor (TNF) and Mitogen-activated protein kinase eight (MAPK8) polymorphisms and low response to hepatitis B vaccines.

methodsA total of 753 infants of HBsAg positive and hepatitis Be antigen (HBeAg) negative mothers from the prevention of mother-to-infant transmission of HBV cohort were included. Five tag single nucleotide polymorphism (SNPs) (rs1799964, rs1800629, rs3093671, rs769177 and rs769178) in TNF and two tag SNPs (rs17780725 and rs3827680) in MAPK8 were genotyped using the MassARRAY platform.

resultsA higher percentage of breastfeeding (P = 0.013) and a higher level of Ab titers were observed in high responders (P < 0.001). The MAPK8 rs17780725 AA genotype increased the risk of low response to hepatitis B vaccines (OR = 3.176, 95% CI: 1.137-8.869). Additionally, subjects with the AA genotype may have a lower Ab titer than subjects with GA or GG genotypes (P = 0.051). Compared to infants who were breastfed, infants who were not breastfed had an increased risk of low response to hepatitis B vaccine (OR = 2.901, 95% CI:1.306-6.441).

conclusionsMAPK8 polymorphisms are associated with immune response to HBV vaccinations in infants of HBsAg(+)/HBeAg(-) mothers.

Indexed as

AdultAllelesFemaleGenotypeHaplotypesHepatitis BHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B VaccinesHumansImmunity, InnateInfantInfant, NewbornInfectious Disease Transmission, VerticalMaleMitogen-Activated Protein Kinase 8Hepatitis B e AntigensHepatitis B Surface AntigensHepatitis B VaccinesMitogen-Activated Protein Kinase 8Tumor Necrosis Factor-alphaHepatitis B vaccinationLow responseMAPK8Mother-to-infant transmissionTNF

Identifiers

PMID29898681
PMCPMC6000919
OpenAlexW2808178307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.