ArticleBMC genomics2018
Cell type-specific analysis of transcriptome changes in the porcine endometrium on Day 12 of pregnancy.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Adaptation of the Porcine Pituitary Transcriptome, Spliceosome and Editome during Early Pregnancy.International journal of molecular sciences · 2023Pooled it
- Identification and expression characteristics of porcine embryonic circRNAs during the peri-implantation.BMC genomics · 2026Article
- Insights into the single-cell transcriptome characteristics of porcine endometrium with embryo loss.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Metabolic reprogramming and heterogeneity during the decidualization process of endometrial stromal cells.Cell communication and signaling : CCS · 2024Article
- Effects of conceptus proteins on endometrium and blood leukocytes of dairy cattle using transcriptome and meta-analysis.bioRxiv : the preprint server for biology · 2024Article
- Copy Number Variation Regions Differing in Segregation Patterns Span Different Sets of Genes.Animals : an open access journal from MDPI · 2023Article
- Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs.BMC genomics · 2023Article
- Integrating Transcriptomic and ChIP-Seq Reveals Important Regulatory Regions Modulating Gene Expression in Myometrium during Implantation in Pigs.Biomolecules · 2022Article
- Effect of miR-143-3p from Extracellular Vesicles of Porcine Uterine Luminal Fluid on Porcine Trophoblast Cells.Animals : an open access journal from MDPI · 2022Article
- Luminal and Glandular Epithelial Cells from the Porcine Endometrium maintain Cell Type-Specific Marker Gene Expression in Air-Liquid Interface Culture.Stem cell reviews and reports · 2022Article
- Effects of exogenous progesterone on the expression of mineral regulatory molecules by ovine endometrium and placentomes†.Biology of reproduction · 2022Article
- Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling†.Biology of reproduction · 2022Article
- Progesterone differentially affects the transcriptomic profiles of cow endometrial cell types.BMC genomics · 2022Article
- Revisiting the Transcriptome Landscape of Pig Embryo Implantation Site at Single-Cell Resolution.Frontiers in cell and developmental biology · 2022Article
- Spatiotemporal endometrial transcriptome analysis revealed the luminal epithelium as key player during initial maternal recognition of pregnancy in the mare.Scientific reports · 2021Article
- Amino acids activate mTORC1 to release roe deer embryos from decelerated proliferation during diapause.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (1): specific signatures of stromal, glandular and luminal epithelial cells.BMC genomics · 2021Article
- Author Correction: Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans.Cell discovery · 2021Article
- Review
- Integrating LCM-Based Spatio-Temporal Transcriptomics Uncovers Conceptus and Endometrial Luminal Epithelium Communication that Coordinates the Conceptus Attachment in Pigs.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlong with trophoblast elongation (Days 10 to 12), estradiol is secreted in increasing amounts for recognition of pregnancy. Endometrial secretions driven by ovarian progesterone and conceptus signals are essential for conceptus growth and development. Results of transcriptome analyses of whole endometrial tissue samples in the pig indicated the need for cell type-specific endometrial gene expression analysis for a better understanding of transcriptome changes associated with establishment of pregnancy.
resultsThe most distinct transcriptome profile and the majority of differentially expressed genes (DEGs) were identified in luminal epithelium (LE). Many DEGs were found only in the cell type-specific analysis. The functional classification of DEGs identified in specific endometrial cell types revealed various distinct functions and pathways. Genes related to immune activation, estrogen signaling pathway, embryo development, and cell proliferation were upregulated in LE of pregnant gilts. Genes involved in sterol biosynthetic and metabolic processes and extracellular matrix were upregulated in stroma. Genes associated with cell communication such as via exosomes and vesicles were found as differential in LE, glandular epithelium (GE), and stroma (S).
conclusionsThis study revealed that conceptus signals induce different transcriptomic regulations in the endometrial compartments/cell types related to their specific function during recognition and establishment of pregnancy.
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