ArticleCell reports2018
Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Enteric-colonizedGut microbes · 2026Article
- Dysregulated adult hippocampal neurogenesis in major depressive disorder.Nature medicine · 2026Article
- Cannabidiol modulates spontaneous recovery through distinct and conserved transcriptomic signatures in mPFC subregions.Communications biology · 2026Article
- Krüppel-Like Factors Modulate Susceptibility To Neuropsychiatric Disorders.Molecular neurobiology · 2025Review
- Krüppel-like factor 9 alleviates Alzheimer's disease via IDE-mediated Aβ degradation.Acta pharmacologica Sinica · 2025Article
- Cryptic genetic variation in brain gene expression precedes the evolution of cannibalism in spadefoot toad tadpoles.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Omics Approaches to Investigate the Pathogenesis of Suicide.Biological psychiatry · 2024Review
- An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience.bioRxiv : the preprint server for biology · 2024Article
- Stress-impaired reward pathway promotes distinct feeding behavior patterns.Frontiers in neuroscience · 2024Article
- Review
- Early-life stress and ovarian hormones alter transcriptional regulation in the nucleus accumbens resulting in sex-specific responses to cocaine.Cell reports · 2023Article
- Postpartum scarcity-adversity inflicts sex-specific cerebellar adaptations and reward behaviors in adolescence.Pharmacology, biochemistry, and behavior · 2023Article
- Loss of Krüppel-like factor 9 deregulates both physiological gene expression and development.Scientific reports · 2023Article
- Genomic regulation of Krüppel-like-factor family members by corticosteroid receptors in the rat brain.Neurobiology of stress · 2023Article
- Structural variation and eQTL analysis in two experimental populations of chickens divergently selected for feather-pecking behavior.Neurogenetics · 2023Article
- Circulating lymphocyte trafficking to the bone marrow contributes to lymphopenia in myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2022Article
- Article
- An Intact Krüppel-like factor 9 Gene Is Required for Acute Liver Period 1 mRNA Response to Restraint Stress.Endocrinology · 2021Article
- Stress and Its Impact on the Transcriptome.Biological psychiatry · 2021Review
- KLF9 regulates PRDX6 expression in hyperglycemia-aggravated bupivacaine neurotoxicity.Molecular and cellular biochemistry · 2021Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Stress exposure is associated with the pathogenesis of psychiatric disorders, including post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). Here, we show in rodents that chronic stress exposure rapidly and transiently elevates hippocampal expression of Kruppel-like factor 9 (Klf9). Inducible genetic silencing of Klf9 expression in excitatory forebrain neurons in adulthood prior to, but not after, onset of stressor prevented chronic restraint stress (CRS)-induced potentiation of contextual fear acquisition in female mice and chronic corticosterone (CORT) exposure-induced fear generalization in male mice. Klf9 silencing prevented chronic CORT and CRS induced enlargement of dendritic spines in the ventral hippocampus of male and female mice, respectively. KLF9 mRNA density was increased in the anterior dentate gyrus of women, but not men, with more severe recent stressful life events and increased mortality. Thus, Klf9 functions as a stress-responsive transcription factor that mediates circuit and behavioral resilience in a sex-specific manner.
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