ArticleJournal of applied oral science : revista FOB2018
In-office tooth bleaching with 38% hydrogen peroxide promotes moderate/severe pulp inflammation and production of ll-1β, TNF-β, GPX, FGF-2 and osteocalcin in rats.
Article in Journal of applied oral science : revista FOB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Assessment of color changes and adverse effects of over-the-counter bleaching protocols: a systematic review and network meta-analysis.Clinical oral investigations · 2024Pooled it
- Efficacy and Tooth Sensitivity of Low- Versus High-Concentration Hydrogen Peroxide for In-Office Bleaching: A Randomized Clinical Trial.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Trial
- Efficacy and safety of low-concentration whitestrips for extrinsic tooth discoloration: a randomized controlled trial.Frontiers in oral health · 2026Trial
- Efficacy and tooth sensitivity of at-home bleaching in patients with esthetic restorations: a randomized clinical trial.Clinical oral investigations · 2022Trial
- Periodontal Indices and Cytokines of Ex-Smokers/Non-Smokers After Bleaching.Medicina (Kaunas, Lithuania) · 2026Article
- Thermal Effects on Dental Pulp during Laser-Assisted Bleaching Procedures with Diode Lasers in a Clinical Study.Journal of clinical medicine · 2024Article
- Chemical painful post-traumatic trigeminal neuropathy induced by dental bleaching: A case report.Journal of clinical and experimental dentistry · 2024Article
- Evaluation of the Pulp Oxygen Saturation Reading after Tooth Bleaching: A Randomized Clinical Trial.International journal of dentistry · 2022Article
- Laboratory model to evaluate efficacy of an experimental titanium oxide nanofibers bleaching agent.Restorative dentistry & endodontics · 2021Article
- Increased whitening efficacy and reduced cytotoxicity are achieved by the chemical activation of a highly concentrated hydrogen peroxide bleaching gel.Journal of applied oral science : revista FOB · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo study the intensity of inflammatory infiltrate and production of interleukin-1β (ll-1β), tumor necrosis factor-β (TNF-β), fibroblast growth factor-2 (FGF-2), glutathione peroxidase (GPX), and osteocalcin in response to in-office tooth bleaching in rats. MATERIAL AND
methodsTwenty male Wistar rats were randomized into four groups (n=5) according to the received treatment (tooth bleaching or no treatment - control) and the period of euthanasia after treatment (24 h or 10 days). We performed tooth bleaching using a 38% hydrogen peroxide gel on maxillary and mandibular incisors. After euthanasia, incisors (20 per group) were processed for histological analysis, immunohistochemistry staining of ll-1β, TNF-β, FGF-2 and GPX and osteocalcin by immunofluorescence. We analyzed data using the Mann-Whitney and Kruskal-Wallis/Dunn tests (p<0.05).
resultsThe bleached groups presented statistically significant differences regarding the pulp inflammation stage compared with the control groups. Bleached teeth showed moderate/severe inflammatory infiltrate and control groups presented absent inflammatory cells or a negligible number of mononuclear cells (p<0.001) at two times (24 h and 10 days). There was strong staining for ll-1β, TNF-β, and GPX in bleached groups at 24 h and strong staining for ll-1β, TNF-β, GPX and FGF-2 at 10 days. After 10 days of tooth bleaching, the bleached group showed a statistically superior amount of osteocalcin than the other groups (p<0.01).
conclusionsTooth bleaching with 38% hydrogen peroxide causes severe pulp inflammation, but characteristics of tissue repair after 10 days.
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Registered trials
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