ArticlePloS one2018
Negative self-referential processing is associated with genetic variation in the serotonin transporter-linked polymorphic region (5-HTTLPR): Evidence from two independent studies.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Acute tryptophan loading decreases functional connectivity between the default mode network and emotion-related brain regions.Human brain mapping · 2019Trial
- 'I am tired, sad and kind': self-evaluation and symptoms of depression in adolescents.Child and adolescent psychiatry and mental health · 2023Article
- Catch the drift: Depressive symptoms track neural response during more efficient decision-making for negative self-referents.Journal of affective disorders reports · 2023Article
- Computational Modeling of Self-Referential Processing Reveals Domain General Associations with Adolescent Anxiety Symptoms.Research on child and adolescent psychopathology · 2023Article
- Self-judgment dissected: A computational modeling analysis of self-referential processing and its relationship to trait mindfulness facets and depression symptoms.Cognitive, affective & behavioral neuroscience · 2023Article
- A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility.Molecular psychiatry · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The current research examined whether carriers of the short 5-HTTLPR allele (in SLC6A4), who have been shown to selectively attend to negative information, exhibit a bias towards negative self-referent processing. The self-referent encoding task (SRET) was used to measure self-referential processing of positive and negative adjectives. Ratcliff's diffusion model isolated and extracted decision-making components from SRET responses and reaction times. Across the initial (N = 183) and replication (N = 137) studies, results indicated that short 5-HTTLPR allele carriers more easily categorized negative adjectives as self-referential (i.e., higher drift rate). Further, drift rate was associated with recall of negative self-referential stimuli. Findings across both studies provide further evidence that genetic variation may contribute to the etiology of negatively biased processing of self-referent information. Large scale studies examining the genetic contributions to negative self-referent processing may be warranted.
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Registered trials
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