ArticlePLoS genetics2018
A subset of plasma membrane-localized PP2C.D phosphatases negatively regulate SAUR-mediated cell expansion in Arabidopsis.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 122 citations in OpenAlex.
- Comparative transcriptome analysis of sesame flower organs and potential functional analysis of the MIKC-MADS gene family.BMC genomics · 2026Article
- Complex Interplay of Tandem, Segmental, Whole Genome Duplication, and Re-organization Drives Expansion of SAUR Gene Family in Brassicaceae.Biochemical genetics · 2026Article
- Article
- Reversible phosphorylation of NPH3/RPT2-like proteins regulates phototropin receptor signaling.The Plant cell · 2026Article
- Dimerization-activated PP2C-D2 and D5 phosphatases negatively regulate brassinosteroid signaling by antagonizing BRI1.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Salicylic acid and ROS signaling modulate hypocotyl elongation in darkness via NPR1 and EX1.Science advances · 2025Article
- Article
- The multifaceted roles of PP2C phosphatases in plant growth, signaling, and responses to abiotic and biotic stresses.Plant communications · 2025Review
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
- Cellular pH homeostasis shapes root system architecture by modulating auxin-mediated developmental responses.Plant physiology · 2025Article
- Harnessing the acid growth theory to optimize apoplastic acidification for enhancing cotton fiber elongation.Plant communications · 2025Article
- Poltergeist-Like 2 (PLL2)-dependent activation of herbivore defence distinguishes systemin from other immune signalling pathways.Nature plants · 2025Article
- A PIF-SAUR module safeguards hypocotyl elongation from ABA inhibition in the dark.Science advances · 2025Article
- How it all begins: molecular players of the early graviresponse in the non-elongating part of flax stem.Plant molecular biology · 2025Article
- The apoplastic pH is a key determinant in the hypocotyl growth response to auxin dosage and light.Nature plants · 2025Article
- TOT3-AHA1 module: its role in fine-tuning stomatal responses.Frontiers in plant science · 2025Review
- Transcriptomic and hormonal dynamics in relation to adventitious rooting of two parentalFrontiers in plant science · 2025Article
- Molecular tipping points in plant cell surface HQuantitative plant biology · 2025Review
- Acidic Stress Induces Cytosolic Free Calcium Oscillation, and an Appropriate Low pH Helps Maintain the Circadian Clock in Arabidopsis.Plants (Basel, Switzerland) · 2024Article
- Systematic Investigation of Aluminum Stress-Related Genes and Their Critical Roles in Plants.International journal of molecular sciences · 2024Review
5 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
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Abstract
The plant hormone auxin regulates numerous growth and developmental processes throughout the plant life cycle. One major function of auxin in plant growth and development is the regulation of cell expansion. Our previous studies have shown that SMALL AUXIN UP RNA (SAUR) proteins promote auxin-induced cell expansion via an acid growth mechanism. These proteins inhibit the PP2C.D family phosphatases to activate plasma membrane (PM) H+-ATPases and thereby promote cell expansion. However, the functions of individual PP2C.D phosphatases are poorly understood. Here, we investigated PP2C.D-mediated control of cell expansion and other aspects of plant growth and development. The nine PP2C.D family members exhibit distinct subcellular localization patterns. Our genetic findings demonstrate that the three plasma membrane-localized members, PP2C.D2, PP2C.D5, and PP2C.D6, are the major regulators of cell expansion. These phosphatases physically interact with SAUR19 and PM H+-ATPases, and inhibit cell expansion by dephosphorylating the penultimate threonine of PM H+-ATPases. PP2C.D genes are broadly expressed and are crucial for diverse plant growth and developmental processes, including apical hook development, phototropism, and organ growth. GFP-SAUR19 overexpression suppresses the growth defects conferred by PP2C.D5 overexpression, indicating that SAUR proteins antagonize the growth inhibition conferred by the plasma membrane-localized PP2C.D phosphatases. Auxin and high temperature upregulate the expression of some PP2C.D family members, which may provide an additional layer of regulation to prevent plant overgrowth. Our findings provide novel insights into auxin-induced cell expansion, and provide crucial loss-of-function genetic support for SAUR-PP2C.D regulatory modules controlling key aspects of plant growth.
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