ArticlePloS one2018
Reemergence of human plague in Yunnan, China in 2016.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Abundance ofPathogens (Basel, Switzerland) · 2026Article
- Influence of natural and anthropogenic drivers on plague risk in Southwest China: A multicenter cross-sectional study.One health (Amsterdam, Netherlands) · 2025Article
- Ancient Origins and Global Diversity of Plague: Genomic Evidence for Deep Eurasian Reservoirs and Recurrent Emergence.Pathogens (Basel, Switzerland) · 2025Article
- Evaluation of human antibodies from vaccinated volunteers for protection againstMicrobiology spectrum · 2024Article
- Phylogenetic Relationships and Evolution of the GenusViruses · 2024Article
- Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics.Communications biology · 2023Article
- Genomic epidemiological analysis of county-scale Yersinia pestis spread pattern over 50 years in a Southwest Chinese prefecture.PLoS neglected tropical diseases · 2023Article
- AncientProceedings. Biological sciences · 2023Article
- Complete mitochondrial genome ofFrontiers in veterinary science · 2023Article
- The efficacy, safety, and immunogenicity of plague vaccines: A systematic literature review.Current research in immunology · 2023Review
- Serological evidence of Yersinia pestis infection in rodents and carnivores in Northwestern Iran.PLoS neglected tropical diseases · 2023Article
- Epidemiological Characteristics of Human and Animal Plague in Yunnan Province, China, 1950 to 2020.Microbiology spectrum · 2022Article
- Knowledge of Emerging and Reemerging Infectious Diseases in the Public of Guangzhou, Southern China.Frontiers in public health · 2022Article
- Human Plague Case Diagnosed in Ningxia Tracked to Animal Reservoirs - Inner Mongolia Autonomous Region, China, 2021.China CDC weekly · 2021Article
- Site 2 of the Yersinia pestis substrate-binding protein YfeA is a dynamic surface metal-binding site.Acta crystallographica. Section F, Structural biology communications · 2021Article
- Article
- A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.PLoS neglected tropical diseases · 2021Article
- Genetic source tracking of human plague cases in Inner Mongolia-Beijing, 2019.PLoS neglected tropical diseases · 2021Article
- Beating the Bio-Terror Threat with Rapid Antimicrobial Susceptibility Testing.Microorganisms · 2021Review
- Improved Selective BIN Agar for a Better Rate of Yersinia pestis Isolation from Primary Clinical Specimens in Suspected Madagascar Plague Cases.Journal of clinical microbiology · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The third plague pandemic originated from Yunnan Province, China in the middle of the 19th century. The last human plague epidemic in Yunnan occurred from 1986-2005. On June 6, 2016, a case of human plague was reported in the Xishuangbanna Prefecture, Yunnan. The patient suffered from primary septicemic plague after exposure to a dead house rat (Rattus flavipectus), which has been identified as the main plague reservoir in the local epizootic area. Moreover, a retrospective investigation identified another bubonic plague case in this area. Based on these data, human plague reemerged after a silent period of ten years. In this study, three molecular typing methods, including a clustered regularly interspaced short palindromic repeats (CRISPR) analysis, different region analysis (DFR), and multiple-locus variable number of tandem repeats analysis (MLVA), were used to illustrate the molecular characteristics of Yersinia pestis (Y. pestis) strains isolated in Yunnan. The DFR profiles of the strains isolated in Yunnan in 2016 were the same as the strains that had previously been isolated in this Rattus flavipectus plague focus. The c3 spacer present in the previously isolated strains was absent in the spacer arrays of the Ypc CRISPR loci of the strains isolated in 2016. The MLVA analysis using MLVA (14+12) showed that the strains isolated from the human plague case and host animal plague infection in 2016 in Yunnan displayed different molecular patterns than the strains that had previously been isolated from Yunnan and adjacent provinces.
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