ArticlePloS one2018
Longitudinal study of body mass index, dyslipidemia, hyperglycemia, and hypertension in 60,000 men and women in Sweden and Austria.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia.Journal of the American Society of Nephrology : JASN · 2022Article
- Dietary Branched-Chain Amino Acids (BCAAs) and Risk of Dyslipidemia in a Chinese Population.Nutrients · 2022Article
- Body mass index and cognitive decline among community-living older adults: the modifying effect of physical activity.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2022Article
- Effects of Body Mass Index, Waist Circumference, Waist-to-Height Ratio and Their Changes on Risks of Dyslipidemia among Chinese Adults: The Guizhou Population Health Cohort Study.International journal of environmental research and public health · 2021Article
- Association between Dietary Patterns and Low HDL-C among Community-Dwelling Elders in North China.Nutrients · 2021Article
- The dynamics of metabolic syndrome development from its isolated components among Iranian adults: findings from 17 years of the Tehran lipid and glucose study (TLGS).Journal of diabetes and metabolic disorders · 2021Article
- Waist-to-height ratio and BMI as predictive markers for insulin resistance in women with PCOS in Kolkata, India.Endocrine · 2021Article
- Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population.Frontiers in genetics · 2021Article
- Prevalence of obesity, metabolic syndrome, diabetes and risk of cardiovascular disease in a psychiatric inpatient sample: results of the Metabolism in Psychiatry (MiP) Study.European archives of psychiatry and clinical neuroscience · 2020Observational
- Obesity-induced sympathoexcitation is associated with Nrf2 dysfunction in the rostral ventrolateral medulla.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Fasting blood glucose level and hypertension risk in aging benign prostatic hyperplasia patients.Aging · 2019Observational
- Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases.GeroScience · 2019Review
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12 authors.
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Abstract
backgroundObesity is suggested to underlie development of other metabolic aberrations, but longitudinal relationships between metabolic factors at various ages has not been studied in detail.
methodsData from 27,379 men and 32,275 women with in total 122,940 health examinations in the Västerbotten Intervention Project, Sweden and the Vorarlberg Health Monitoring and Prevention Programme, Austria were used to investigate body mass index (BMI), mid-blood pressure, and fasting levels of glucose, triglycerides, and total cholesterol at baseline in relation to 10-year changes of these factors and weight. We included paired examinations performed 10±2 years apart and used them for longitudinal analysis with linear regression of changes between the ages 30 and 40, 40 and 50, or 50 and 60 years.
resultsHigher levels of BMI were associated with increases in glucose and mid-blood pressure as well as triglycerides levels, and, to a lesser extent, decreases in cholesterol levels. For instance, per 5 kg/m2 higher BMI at age 40, glucose at age 50 increased by 0.24 mmol/l (95%CI: 0.22-0.26) and mid-blood pressure increased by 1.54 mm Hg (95%CI: 1.35-1.74). The strongest association observed was between BMI at age 30 and mid-blood pressure, which was 2.12 mm Hg (95% CI: 1.79-2.45) increase over ten years per 5 kg/m2 higher BMI level. This association was observed at an age when blood pressure levels on average remained stable. Other associations than those with BMI at baseline were much weaker. However, triglyceride levels were associated with future glucose changes among individuals with elevated BMI, particularly in the two older age groups.
conclusionBMI was most indicative of long-term changes in metabolic factors, and the strongest impact was observed for increases in blood pressure between 30 and 40 years of age. Our study supports that lifestyle interventions preventing metabolic aberrations should focus on avoiding weight increases.
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