ArticlePLoS computational biology2018
A biophysical mechanism for preferred direction enhancement in fly motion vision.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 38 citations in OpenAlex.
- Distribution and voltage dependence of ion channels shape single-neuron computations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Homotypic dendritic interactions constrain growth and receptor distribution in Drosophila T4 neurons without affecting orientation or function.Development (Cambridge, England) · 2026Article
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- Optimization in Visual Motion Estimation.Annual review of vision science · 2024Review
- Multilevel visual motion opponency in Drosophila.Nature neuroscience · 2023Article
- Optic flow based spatial vision in insects.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- Excitatory and inhibitory neural dynamics jointly tune motion detection.Current biology : CB · 2022Article
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- Predicting individual neuron responses with anatomically constrained task optimization.Current biology : CB · 2021Article
- Quantitative Characterization of Output from the Directionally Selective Visual Interneuron H1 in the Grey Flesh FlyJournal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2021Article
- Autonomous Flying With Neuromorphic Sensing.Frontiers in neuroscience · 2021Article
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- How fly neurons compute the direction of visual motion.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- A minimal synaptic model for direction selective neurons in Drosophila.Journal of vision · 2020Article
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- Article
- The Neuronal Basis of an Illusory Motion Percept Is Explained by Decorrelation of Parallel Motion Pathways.Current biology : CB · 2018Article
- Glutamate Signaling in the Fly Visual System.iScience · 2018Article
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1 author at 1 institution in 1 country.
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Abstract
Seeing the direction of motion is essential for survival of all sighted animals. Consequently, nerve cells that respond to visual stimuli moving in one but not in the opposite direction, so-called 'direction-selective' neurons, are found abundantly. In general, direction selectivity can arise by either signal amplification for stimuli moving in the cell's preferred direction ('preferred direction enhancement'), signal suppression for stimuli moving along the opposite direction ('null direction suppression'), or a combination of both. While signal suppression can be readily implemented in biophysical terms by a hyperpolarization followed by a rectification corresponding to the nonlinear voltage-dependence of the Calcium channel, the biophysical mechanism for signal amplification has remained unclear so far. Taking inspiration from the fly, I analyze a neural circuit where a direction-selective ON-cell receives inhibitory input from an OFF cell on the preferred side of the dendrite, while excitatory ON-cells contact the dendrite centrally. This way, an ON edge moving along the cell's preferred direction suppresses the inhibitory input, leading to a release from inhibition in the postsynaptic cell. The benefit of such a two-fold signal inversion lies in the resulting increase of the postsynaptic cell's input resistance, amplifying its response to a subsequent excitatory input signal even with a passive dendrite, i.e. without voltage-gated ion channels. A motion detector implementing this mechanism together with null direction suppression shows a high degree of direction selectivity over a large range of temporal frequency, narrow directional tuning, and a large signal-to-noise ratio.
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