ArticlePLoS computational biology2018
3D morphology-based clustering and simulation of human pyramidal cell dendritic spines.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- 3D dendritic spines shape descriptors for efficient classification and morphology analysis in control and Alzheimer's disease modeling neurons.Bioinformatics (Oxford, England) · 2026Article
- Article
- VSOT: volume-surface optimization for accurate ultrastructure analysis of dendritic spines.Bioinformatics (Oxford, England) · 2025Article
- Distribution of spine classes shows intra-neuronal dendritic heterogeneity in mouse cortex.Neurophotonics · 2025Article
- A modular framework for multi-scale tissue imaging and neuronal segmentation.Nature communications · 2024Article
- Distinct forms of structural plasticity of adult-born interneuron spines in the mouse olfactory bulb induced by different odor learning paradigms.Communications biology · 2024Article
- Between neurons and networks: investigating mesoscale brain connectivity in neurological and psychiatric disorders.Frontiers in neuroscience · 2024Review
- Whole human-brain mapping of single cortical neurons for profiling morphological diversity and stereotypy.Science advances · 2023Article
- SpineTool is an open-source software for analysis of morphology of dendritic spines.Scientific reports · 2023Article
- Introduction: What Are Dendritic Spines?Advances in neurobiology · 2023Article
- NeuroSuites: An online platform for running neuroscience, statistical, and machine learning tools.Frontiers in neuroinformatics · 2023Article
- Dendritic Spines: Synaptogenesis and Synaptic Pruning for the Developmental Organization of Brain Circuits.Advances in neurobiology · 2023Article
- Morphological Features of Human Dendritic Spines.Advances in neurobiology · 2023Review
- Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an "all-or-nothing" communication switch between the spine head and dendrite.PLoS computational biology · 2022Article
- Hyperacute Excitotoxic Mechanisms and Synaptic Dysfunction Involved in Traumatic Brain Injury.Frontiers in molecular neuroscience · 2022Review
- Gene expression profiles in the brain of phenylketonuria mouse model reversed by the low phenylalanine diet therapy.Metabolic brain disease · 2021Article
- Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies.Developmental neurobiology · 2021Article
- The Subcortical-Allocortical- NeocorticalFrontiers in synaptic neuroscience · 2021Article
- Effects of sleep and waking on the synaptic ultrastructure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Dendritic Spines Shape Analysis-Classification or Clusterization? Perspective.Frontiers in synaptic neuroscience · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dendritic spines of pyramidal neurons are the targets of most excitatory synapses in the cerebral cortex. They have a wide variety of morphologies, and their morphology appears to be critical from the functional point of view. To further characterize dendritic spine geometry, we used in this paper over 7,000 individually 3D reconstructed dendritic spines from human cortical pyramidal neurons to group dendritic spines using model-based clustering. This approach uncovered six separate groups of human dendritic spines. To better understand the differences between these groups, the discriminative characteristics of each group were identified as a set of rules. Model-based clustering was also useful for simulating accurate 3D virtual representations of spines that matched the morphological definitions of each cluster. This mathematical approach could provide a useful tool for theoretical predictions on the functional features of human pyramidal neurons based on the morphology of dendritic spines.
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