Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2018
Energy compensation in response to aerobic exercise training in overweight adults.
Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The effects of exercise interventions on weight regain after weight loss: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Fasting appetite-related gut hormone responses after weight loss induced by calorie restriction, exercise, or both in people with overweight or obesity: a meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Effect of exercise training interventions on energy intake and appetite control in adults with overweight or obesity: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Aerobic exercise elevates perceived appetite but does not modify energy intake over a 3-day postexercise period: A pilot study.Physiological reports · 2024Trial
- Combined training and hormones/enzymes with insulinotropic actions in individuals with overweight and type 2 diabetes mellitus: A randomized controlled trial.European journal of sport science · 2024Trial
- Exercise increases attentional bias towards food cues in individuals classified as overweight to obese.Physiology & behavior · 2022Trial
- Exercise for Weight Loss: Further Evaluating Energy Compensation with Exercise.Medicine and science in sports and exercise · 2020Trial
- Multilevel metabolic adaptation to exercise training.Communications medicine · 2026Article
- Physical activity substitution: An overlooked constraint on energy expenditure during exercise and physical activity interventions.Diabetes, obesity & metabolism · 2025Article
- Exploring Strategies to Promote Exercise as a Viable Obesity and Chronic Disease Treatment.Nutrients · 2025Review
- Cumulative effects of training at different weekly energy expenditures on cardiorespiratory fitness and markers of metabolic syndrome in STRRIDE-Extension.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Gradual increase in energy intake over 8 weeks with voluntary wheel running limits body weight change in male rats.The British journal of nutrition · 2025Article
- Combined Aerobic Exercise with Intermittent Fasting Is Effective for Reducing mTOR and Bcl-2 Levels in Obese Females.Sports (Basel, Switzerland) · 2024Article
- Breaking prolonged sitting increases 24-h physical activity and self-perceived energy levels but does not acutely affect cognition in healthy adults.European journal of applied physiology · 2024Article
- Clinical-epidemiological assessment of patients undergoing bariatric and metabolic surgery in a medium-complexity service in Maranhão, Brazil.Revista do Colegio Brasileiro de Cirurgioes · 2024Article
- Compensatory Responses to Exercise Training As Barriers to Weight Loss: Changes in Energy Intake and Non-exercise Physical Activity.Current nutrition reports · 2023Review
- The aorta in humans and African great apes, and cardiac output and metabolic levels in human evolution.Scientific reports · 2023Article
- Altered motivation states for physical activity and 'appetite' for movement as compensatory mechanisms limiting the efficacy of exercise training for weight loss.Frontiers in psychology · 2023Article
- Reactive Oxygen Species (ROS) and Antioxidants as Immunomodulators in Exercise: Implications for Heme Oxygenase and Bilirubin.Antioxidants (Basel, Switzerland) · 2022Review
- Energy compensation and adiposity in humans.Current biology : CB · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weight loss from exercise is often less than expected. Putative compensatory mechanisms may limit exercise-induced reductions in body fat and might be proportional to exercise energy expenditure (ExEE). This study was conducted to determine compensation for (the difference between accumulated exercise energy expenditure and changes in body tissue energy stores) and compensatory responses to 1,500 or 3,000 kcal/wk of ExEE. Overweight-to-obese ( n = 36) sedentary men and women were randomized to groups expending 300 or 600 kcal/exercise session, 5 days/wk, for 12 wk. Fourteen participants in the 300-kcal group and 15 in the 600-kcal group completed the study. The primary outcome was energy compensation assessed through changes in body tissue energy stores. Secondary outcomes were putative compensatory responses of resting metabolic rate, food reinforcement, dietary intake, and serum acylated ghrelin and glucagon-like peptide-1. All measures were determined pre- and posttraining. The 3,000 kcal/wk group decreased ( P < 0.01) percentage and kilograms of body fat, while the 1,500 kcal/wk group did not. The 1,500 and 3,000 kcal/wk groups compensated for 943 (-164 to 2,050) and 1,007 (32 to 1,982) kcal/wk (mean, 95% CI, P ≥ 0.93), or 62.9% and 33.6% of ExEE, respectively. Resting metabolic rate and energy intake did not change. Food reinforcement and glucagon-like peptide-1 decreased ( P < 0.02), whereas acylated ghrelin increased ( P ≤ 0.02). Compensation is not proportional to ExEE. Similar energy compensation occurred in response to1,500 and 3,000 kcal/wk of ExEE. ExEE of 3,000 kcal/wk is sufficient to exceed compensatory responses and reduce fat mass.
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