ArticleMicrobiologyOpen2019
The stress hormone norepinephrine increases the growth and virulence of Aeromonas hydrophila.
Article in MicrobiologyOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Engineering inter-kingdom adrenergic signaling in commensals couples host stress hormone sensing to programmable biological outputs.PLoS biology · 2026Article
- Antibacterial Mechanism of Allicin E AgainstAntibiotics (Basel, Switzerland) · 2026Article
- Dopamine Is a Key Regulatory Molecule forMicroorganisms · 2026Article
- Natural and synthetic chemicals acting as enhancers of bacterial pathogenic success within the human host.Frontiers in cellular and infection microbiology · 2026Review
- Psychobiotics in Aquaculture: Harnessing the Microbiome-Gut-Brain Axis for Stress Management and Production Enhancement in Fish.Animals : an open access journal from MDPI · 2025Review
- Effects of the stress hormone norepinephrine on the probiotic properties ofFrontiers in microbiology · 2025Article
- The Role of Macronutrients and Gut Microbiota in Neuroinflammation Post-Traumatic Brain Injury: A Narrative Review.Nutrients · 2024Review
- Effects of Catecholamine Stress Hormones Norepinephrine and Epinephrine on Growth, Antimicrobial Susceptibility, Biofilm Formation, and Gene Expressions of EnterotoxigenicInternational journal of molecular sciences · 2023Article
- Carvacrol Inhibits Quorum Sensing in Opportunistic BacteriumMicroorganisms · 2023Article
- In Vitro Antibiofilm Activity of Resveratrol againstAntibiotics (Basel, Switzerland) · 2023Article
- Effects of glycyrrhetinic acid β on growth and virulence ofFrontiers in microbiology · 2023Article
- The antivirulence activity, transcriptomics of EGCG and its protective effects on zebrafish infected byFrontiers in cellular and infection microbiology · 2023Article
- Antimicrobial and Antivirulence Activities of Carvacrol against PathogenicMicroorganisms · 2022Article
- Molecular Epidemiology, Virulence Traits and Antimicrobial Resistance Signatures ofAntibiotics (Basel, Switzerland) · 2021Article
- Evaluation of the gut microbiome in association with biological signatures of inflammation in murine polytrauma and shock.Scientific reports · 2021Article
- Inter-Kingdom Signaling of Stress Hormones: Sensing, Transport and Modulation of Bacterial Physiology.Frontiers in microbiology · 2021Review
- Reduced Plasma Dopamine-β-Hydroxylase Activity Is Associated With the Severity of Bipolar Disorder: A Pilot Study.Frontiers in psychiatry · 2021Article
- Epinephrine affects motility, and increases adhesion, biofilm and virulence of Pseudomonas aeruginosa H103.Scientific reports · 2019Article
- The stress hormone norepinephrine increases the growth and virulence of Aeromonas hydrophila.MicrobiologyOpen · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress is an important contributing factor in the outbreak of infectious fish diseases. To comprehensively understand the impact of catecholamine stress hormone norepinephrine (NE) on the pathogenicity of Aeromonas hydrophila, we assessed variations in bacterial growth, virulence-related genes expression and virulence factors activity after NE addition in serum-SAPI medium. Further, we assessed the effects of NE on A. hydrophila virulence in vivo by challenging fish with pathogenic strain AH196 and following with or without NE injection. The NE-associated stimulation of A. hydrophila strain growth was not linear-dose-dependent, and only 100 μM, or higher concentrations, could stimulate growth. Real-time PCR analyses revealed that NE notably changed 13 out of the 16 virulence-associated genes (e.g. ompW, ahp, aha, ela, ahyR, ompA, and fur) expression, which were all significantly upregulated in A. hydrophila AH196 (p < 0.01). NE could enhance the protease activity, but not affect the lipase activity, hemolysis, and motility. Further, the mortality of crucian carp challenged with A. hydrophila AH196 was significantly higher in the group treated with NE (p < 0.01). Collectively, our results showed that NE enhanced the growth and virulence of pathogenic bacterium A. hydrophila.
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