Evidence map›Paper›PMID 29897662›Full record

ReviewMolecular oral microbiology2018

Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome.

Sylvio Redanz, Xingqun Cheng, Rodrigo A Giacaman, Carmen S Pfeifer, Justin Merritt, Jens Kreth

Abstract readReview
In one paragraph

Review in Molecular oral microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Trial
  2. HApplied and environmental microbiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. AJournal of bacteriology · 2026
    Review
  8. Article
  9. Article
  10. Oral hygiene agents at work: effects onFrontiers in cellular and infection microbiology · 2026
    Review
  11. Article
  12. Article
  13. Complete genome sequence ofMicrobiology resource announcements · 2025
    Article
  14. Article
  15. Journal of bacteriology · 2025
    Review
  16. Review
  17. Article
  18. A strain ofApplied and environmental microbiology · 2025
    Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sylvio RedanzDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon.
Xingqun ChengThe State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Rodrigo A GiacamanCariology Unit, Department of Oral Rehabilitation and Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), University of Talca, Talca, Chile.ORCID 0000-0003-3362-5173
Carmen S PfeiferDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon.
Justin MerrittDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon.
Jens KrethDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0002-8599-8310

Funding

The IrvA-Dependent Pathway: A Link Between Stress Adaptation and VirulenceR01DE018893 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MERRITT, JUSTIN · 2009 to 2018
$3.0M
Tertiary methacrylamides and thiourethane additives as novel dental compositesU01DE023756 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI FERRACANE, JACK L., PFEIFER, CARMEM S. · 2013 to 2017
$2.4M
Pyruvate oxidase determines ecological fitness of oral streptococciR01DE021726 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI KRETH, JENS · 2014 to 2018
$1.9M
The LytTR Regulatory Systems of Streptococcus mutansR01DE022083 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MERRITT, JUSTIN · 2013 to 2016
$1.5M
Novel dental composites based on methacrylamides and thiourethane oligomersK02DE025280 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI PFEIFER, CARMEM S. · 2016 to 2020
$600k
Pyruvate oxidase determines ecological fitness of oral streptococciR56DE021726 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2018 to 2018
$545k
A Novel Class of Signal Transduction System in Streptococcus mutansR21DE023850 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MERRITT, JUSTIN · 2014 to 2015
$418k
NIDCR NIH HHS K02 DE025280NIDCR NIH HHS R01 DE018893NIDCR NIH HHS R01 DE021726NIDCR NIH HHS R01 DE022083NIDCR NIH HHS R21 DE023850NIDCR NIH HHS R56 DE021726NIDCR NIH HHS U01 DE023756
6 · The paper itself

Abstract

The majority of commensal oral streptococci are able to generate hydrogen peroxide (H

Indexed as

MicrobiotaSymbiosisBiofilmsHumansHydrogen PeroxideOral HealthPyruvate OxidaseStreptococcusHydrogen PeroxidePyruvate Oxidasebiofilmshydrogen peroxidestreptococci

Identifiers

PMID29897662
PMCPMC6158098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.