ArticleCerebral cortex (New York, N.Y. : 1991)2019
Prefrontal D1 Dopamine-Receptor Neurons and Delta Resonance in Interval Timing.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Cortical dopaminergic signaling mediates planning of directional movements.Science advances · 2025Article
- Amphetamine increases timing variability by degrading prefrontal temporal encoding.Neuropharmacology · 2025Article
- Generation and validation of a D1 dopamine receptor Flpo knock-in mouse.Journal of neuroscience methods · 2025Article
- From emotional arousal to executive action. Role of the prefrontal cortex.Brain structure & function · 2024Review
- Glycolysis-enhancing αNPJ Parkinson's disease · 2023Article
- Anesthesia and analgesia for experimental craniotomy in mice and rats: a systematic scoping review comparing the years 2009 and 2019.Frontiers in neuroscience · 2023Article
- Novelty-induced frontal-STN networks in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Phase-adaptive brain stimulation of striatal D1 medium spiny neurons in dopamine-depleted mice.Scientific reports · 2022Article
- Interval timing and midfrontal delta oscillations are impaired in Parkinson's disease patients with freezing of gait.Journal of neurology · 2022Article
- A pilot study of machine learning of resting-state EEG and depression in Parkinson's disease.Clinical parkinsonism & related disorders · 2022Article
- Neuromodulation of cognition in Parkinson's disease.Progress in brain research · 2022Review
- Cortical alpha-synuclein preformed fibrils do not affect interval timing in mice.Neuroscience letters · 2021Article
- Stay or go? Neuronal activity in medial frontal cortex during a voluntary tactile preference task in head-fixed mice.Cell calcium · 2021Article
- Medial prefrontal cortex and the temporal control of action.International review of neurobiology · 2021Review
- Mediodorsal Thalamus Contributes to the Timing of Instrumental Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Corticostriatal stimulation compensates for medial frontal inactivation during interval timing.Scientific reports · 2019Article
- Entrained neuronal activity to periodic visual stimuli in the primate striatum compared with the cerebellum.eLife · 2019Article
- Scopolamine and Medial Frontal Stimulus-Processing during Interval Timing.Neuroscience · 2019Article
- Dopamine Modulation of Prefrontal Cortex Activity Is Manifold and Operates at Multiple Temporal and Spatial Scales.Cell reports · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Considerable evidence has shown that prefrontal neurons expressing D1-type dopamine receptors (D1DRs) are critical for working memory, flexibility, and timing. This line of work predicts that frontal neurons expressing D1DRs mediate cognitive processing. During timing tasks, one form this cognitive processing might take is time-dependent ramping activity-monotonic changes in firing rate over time. Thus, we hypothesized the prefrontal D1DR+ neurons would strongly exhibit time-dependent ramping during interval timing. We tested this idea using an interval-timing task in which we used optogenetics to tag D1DR+ neurons in the mouse medial frontal cortex (MFC). While 23% of MFC D1DR+ neurons exhibited ramping, this was significantly less than untagged MFC neurons. By contrast, MFC D1DR+ neurons had strong delta-frequency (1-4 Hz) coherence with other MFC ramping neurons. This coherence was phase-locked to cue onset and was strongest early in the interval. To test the significance of these interactions, we optogenetically stimulated MFC D1DR+ neurons early versus late in the interval. We found that 2-Hz stimulation early in the interval was particularly effective in rescuing timing-related behavioral performance deficits in dopamine-depleted animals. These findings provide insight into MFC networks and have relevance for disorders such as Parkinson's disease and schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.