Evidence map›Paper›PMID 29897287›Full record

ArticleAmerican journal of physiology. Renal physiology2018

The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction.

Ashley R Jackson, Birong Li, Shira H Cohen, Christina B Ching, Kirk M McHugh, Brian Becknell

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

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  11. Krt5American journal of physiology. Renal physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ashley R JacksonCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital , Columbus, Ohio.
Birong LiCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital , Columbus, Ohio.
Shira H CohenCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital , Columbus, Ohio.
Christina B ChingCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital , Columbus, Ohio.
Kirk M McHughCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital , Columbus, Ohio.
Brian BecknellCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital , Columbus, Ohio.ORCID 0000-0002-2750-4415
Nationwide Children's Hospital · US

Funding

Model of Congenital Obstructive Nephropathy-Biomarker & Therapeutic DevelopmentR01DK085242 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BATES, CARLTON MATTHEW, MCHUGH, KIRK M. · 2010 to 2014
$1.6M
Role of urothelium in epithelial integrity and innate defense of the kidneyK08DK102594 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BECKNELL, BRIAN · 2015 to 2019
$745k
Context Specific Roles of Renal Urothelial Cells in Development and Obstructive NephropathyF32DK115085 · NIDDK · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI JACKSON, ASHLEY R. · 2017 to 2019
$179k
NIDDK NIH HHS F32 DK115085NIDDK NIH HHS K08 DK102594NIDDK NIH HHS R01 DK085242
6 · The paper itself

Abstract

Urinary tract obstruction represents a common cause of kidney injury across the human life span, resulting in chronic kidney disease and end-stage renal disease. Yet, the extent of obstructive renal damage can be heterogeneous between individuals, implying the existence of unknown mechanisms that protect against or accelerate kidney injury. In this study, we investigated the role of urothelial remodeling in renal adaptation during congenital and acquired obstruction. In the Megabladder ( Mgb

Indexed as

AnimalsDisease Models, AnimalHydronephrosisKidneyKidney Failure, ChronicMice, Inbred C57BLMice, TransgenicRenal InsufficiencyUreteral ObstructionUroplakinsUrotheliumUroplakinsobstructive nephropathyrenal urotheliumurinary tract obstructionuroplakinurothelial plaque

Identifiers

PMID29897287
PMCPMC6230727
OpenAlexW2808297896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.