ArticleBJPsych open2018
Magnesium and mood disorders: systematic review and meta-analysis.
Article in BJPsych open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Identifying transdiagnostically relevant risk and protective factors for internalizing psychopathology: An umbrella review of longitudinal meta-analyses.Journal of psychiatric research · 2023Pooled it
- Pooled it
- Is Magnesium Supplementation an Effective Nutritional Method to Reduce Stress in Domestic Pigs? A Systematic Review.Frontiers in veterinary science · 2020Pooled it
- Vitamin D Deficiency and 3-Year Risk of New-Onset Depression After Metabolic and Bariatric Surgery: A Longitudinal Cohort Study.Obesity surgery · 2026Article
- Anxiety severity among adults having upper gastrointestinal symptoms: Proportion and predictors - A cross-sectional study.Bioinformation · 2025Article
- [Procedures of complementary medicine in rheumatology].Zeitschrift fur Rheumatologie · 2024Review
- Associations between Chronic Medical Conditions and Persistent Dietary Supplement Use: The US Military Dietary Supplement Use Study.Nutrients · 2024Article
- Magnesium (MgCurrent pharmaceutical design · 2024Review
- Gathering the Evidence on Diet and Depression: A Protocol for an Umbrella Review and Updated Meta-Analyses.Methods and protocols · 2023Article
- Associations between clinically diagnosed medical conditions and dietary supplement use: the US military dietary supplement use study.Public health nutrition · 2023Article
- Nutrition and behavioral health disorders: depression and anxiety.Nutrition reviews · 2021Review
- Total and ionized calcium and magnesium are significantly lowered in drug-naïve depressed patients: effects of antidepressants and associations with immune activation.Metabolic brain disease · 2019Article
- The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMagnesium (Mg2+) has received considerable attention with regards to its potential role in the pathophysiology of the mood disorders, but the available evidence seems inconclusive.AimsTo review and quantitatively summarise the human literature on Mg2+ intake and Mg2+ blood levels in the mood disorders and the effects of Mg2+ supplements on mood.
methodSystematic review and meta-analyses.
resultsAdherence to a Mg2+-rich diet was negatively associated with depression in cross-sectional (odds ratio = 0.66) but not in prospective studies. Mg2+ levels in bodily fluids were on average higher in patients with a mood disorder (Hedge's g = 0.19), but only in patients treated with antidepressants and/or mood stabilisers. There was no evident association between Mg2+ levels and symptom severity. Mg2+ supplementation was associated with a decline in depressive symptoms in uncontrolled (g = -1.60) but not in placebo-controlled trials (g = -0.21).
conclusionOur results provide little evidence for the involvement of Mg2+ in the mood disorders.Declaration of interestNone.
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