Evidence map›Paper›PMID 29896529›Full record

ArticleData in brief2018

Data on the effects of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on intraocular pressure of ocular normotensive rats.

Adrian Julian Marcus, Igor Iezhitsa, Renu Agarwal, Pavel Vassiliev, Alexander Spasov, Olga Zhukovskaya, Vera Anisimova, Nafeeza Mohd Ismail

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Adrian Julian MarcusCentre for Neuroscience Research, Faculty of Medicine, Universiti Teknologi MARA, Malaysia.
Igor IezhitsaCentre for Neuroscience Research, Faculty of Medicine, Universiti Teknologi MARA, Malaysia.
Renu AgarwalCentre for Neuroscience Research, Faculty of Medicine, Universiti Teknologi MARA, Malaysia.
Pavel VassilievVolgograd State Medical University, Research Institute of Pharmacology, Volgograd, Russia.
Alexander SpasovVolgograd State Medical University, Research Institute of Pharmacology, Volgograd, Russia.
Olga ZhukovskayaSouthern Federal University, Research Institute of Physical and Organic Chemistry, Rostov-on-Don, Russia.
Vera AnisimovaSouthern Federal University, Research Institute of Physical and Organic Chemistry, Rostov-on-Don, Russia.
Nafeeza Mohd IsmailCentre for Neuroscience Research, Faculty of Medicine, Universiti Teknologi MARA, Malaysia.
Universiti Teknologi MARA · MYVolgograd State Medical University · RUSouthern Federal University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This data is to document the intraocular pressure (IOP) lowering activity of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats. Effects of single drop application of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on IOP in ocular normotensive rats are presented at 3 different concentrations (0.1%, 0.2% and 0.4%). Time course of changes in IOP is presented over 6 h period post-instillation. The IOP lowering activities of test compounds were determined by assessing maximum decrease in IOP from baseline and corresponding control, duration of IOP lowering and area under curve (AUC) of time versus response curve. Data shown here may serve as benchmarks for other researchers studying IOP-lowering effect of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds and would be useful in determining therapeutic potential of these test compounds as IOP lowering agents.

Indexed as

Drug screeningImidazo[1,2-a]benzimidazolesIntraocular pressureIntraocular pressure lowering activityOcular normotensive ratsPyrimido[1,2-a]benzimidazolesRebound tonometry

Identifiers

PMID29896529
PMCPMC5996230
OpenAlexW2790774269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.